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Distinct structural bases of the immunoregulatory and central analgesic effects of IFNα

WANG Yun Xia 1,2 ,JIANG Chun Lei 1,** ,SONG Lian Xia 1,2 ,LU Chang Lin 1,SHAO Xiao Yan 3, YOU Zhen Dong 1,HUANG Ai Jun 1,CUI Rui Yao 2,LIU Xin Yuan 3(~ 1Department of Neurobiology, Second Military Medical University, Shanghai  
Interferon alpha (IFNα), a cytokine, is also an analgesic molecule. There is significant cross reactivity between IFNα and anti opioid sera, suggesting a strong antigenic relatedness between human IFNα molecules and opioid peptides. Different structural basis of the immunoactivity and analgesic effect of IFNα can be demonstrated by different reactivities of the two reactions towards different mutants of IFNα obtained by using the site directed mutagenesis. When the 129th Tyr residue of human IFNα was mutated to Ser, the immunoactivity of the mutant almost disappeared, while the strong analgesic activity still persisted, which could be blocked by naloxone. These results indicate that there exist distinct domains in the IFNα molecule, which mediate immune and analgesic effects differentially, and that the receptor mechanism underlying immune and analgesic effects of IFNα may be different.
【Fund】: ThisworkwassupportedbyShanghaiEducationalDevelopmentFoundation ( 97SG1 6)andNationalNaturalScienceFoundationofChina ( 39570 669)
【CateGory Index】: R392
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