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《Acta Physiological Sinica》 2003-04
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Effect of peroxynitrite on the reactivity of rabbit pulmonary arteries in vitro

GU Zhen-Yong~1,2, LING Yi-Ling~2, XU Xiao-Hu~1, MENG Ai-Hong~2, LI Shu-Jin~2 1 Shantou University Medical College, Shantou 515031; 2 Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017  
To investigate the effect of peroxynitrite (ONOO~-) on the reactivity of rabbit pulmonary artery,the responses of rabbit pulmonary artery tings (PARs) pre-incubated with ONOO~- to endothelium-dependent and receptor-dependent relaxants ACh and ADP, endothelium-dependent and receptor-independent relaxant calcium ionophore A23187, endothelium-independent relaxant sodium nitroprusside (SNP) and α1-adrenoceptor agonist phenylephrine (PE) were observed in vitro in an accumulative manner. (1) Relaxations of PARs to ACh, calcium ionophore A23187 and ADP were markedly impaired with shift of accumulative doseresponse curve of each agonist to the tight. Inhibition of endothelium-dependent and receptor-dependent or independent relaxation by ONOO~- was dose-dependent. (2)ONOO~- incubation inhibited SNP-induced relaxation in a dose-dependent manner. (3) Contractile response of PARs to PE varied with the different doses of ONOO~-. In PARs pre-incubated with 0.5 mmol/L ONOO~-, contractile response was significantly enhanced with shift of PE accumulative dose-response curve to the left, whereas in PARs pre-incubated with 1.0 mmol/L or 2.0 mmol/L ONOO~-, it was markedly reduced with right shift of PE accumulative dose-response curve.(4) Vehicle of ONOO~- had no effect on responses to each agonist. Decomposed ONOO~- had minimal effect on the response to PE and ADP, in contrast, relaxation of PARs to ACh, A23187 and SNP were enhanced. These results indicate that ONOO~- may contribute to regulatory disorder of pulmonary artery reactivity.
【Fund】: This work was supported by the National Natural Science Foundation of China (No. 39870317).
【CateGory Index】: R363
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【References】
Chinese Journal Full-text Database 2 Hits
1 WANG Hui-yun1,YAN Jun1,XIANG Jian1,ZHAO Li-xiang1,GU Zhen-yong1,2(1.Department of Forensic Medicine,Medical College of Soochow University,Suzhou 215123,China;2.Department of Forensic Medicine,Medical College of Nantong University,Nantong 226001,China);Effect of Soft Tissue Crush Injury on Tensions of Thoracic Aortic Rings in Rats[J];Journal of Forensic Medicine;2011-02
2 ZHANG Jianxin,LI Lanfang,SHANG Tao.Hebei Academy of Medical Sciences,Shijiazhuang 050021;Effect of aminoguanidine and L-arginine on mitochondria injury in acute lung injury rats induced by endotoxin[J];Hebei Medical Journal;2009-04
【Citations】
Chinese Journal Full-text Database 4 Hits
1 GU Zhen Yong, LING Yi Ling , LI Shu Jin, MENG Ai Hong, ZHANG Jun Lan (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017);Properties of peroxynitrite-induced relaxation in rabbit pulmonary artery in vitro[J];Acta Physiological Sinica;2001-04
2 DUAN Guo-Chen, LING Yi-Ling *, GU Zhen-Yong, WEI Peng, NIU Zhi-Yun, YANG Shi-FangDepartment of Pathophysiology, Hebei Medical University, Shijiazhuang 050017;Effects of cholecystokinin-octapeptide on the tension of pulmonary artery in rabbits with endotoxic shock[J];Acta Physiological Sinica;2003-02
3 GU Zhen-Yong, LING Yi-Ling, MENG Ai-Hong, CONG Bin, HUANG Shan-Sheng Department of Pathophysiology, Hebei Medical University, Shijiazhuang(050017);Effects of cholecystokinin octapeptide on the response of rabbit pulomonary artery induced by LPS in vitro[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1999-06
4 GUZhenyong ,LING Yiling,CONGBin ,etal DepartmentofPathophysiology,HebeiMedicalUniversity ,Shijiazhuang 0 5 0 0 17, China;Peroxynitrite mediated acute lung injury induced by lipopolysaccharides in rats[J];NATIONAL MEDICAL JOURNAL OF CHINA;2000-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 MA Li-Qin, GU Zhen-Yong, DONG Guo-Kai, LI Na, GAO Feng, LIU Xia, MA Chun-Ling, CONG Bin, LING Yi-Ling Department of Forensic Medicine and Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China;Effect of cholecystokinin octapeptide on LPS-induced SOD mRNA expression and increase of NF-κB activity in rat vascular smooth muscle cells induced by LPS[J];Journal of the Fourth Military Medical University;2006-20
2 Wang Xiaoyuan, Xia Zhongyuan, Du Daping,et al Department of Anesthesiology, Renmin Hospital, Wuhan University, Wuhan 430060, China;Role of HO-1/CO in Lipopolysaccharide-induced Acute Lung Injury and the Effect of Sodium Nitroprusside on It[J];Journal of Hubei Medical University;2005-01
3 CAO De-quan~(1,*),CHEN Yan-ping~(1),CHANG Ye-tian~(1),LI Yong-guo~(2)(1.Department of Anesthesiology;2.Department of General Surgery,Second Xiangya Hospital,Central South University,Changsha 410011,China);Effects of aminoguanidine on the lung injury induced by the total hepatic ischemia-reperfusion in rats[J];Journal of Central South University(Medical Sciences);2006-01
4 ;Effects of the Extract of Gingko Leaf Ginaton on Acute Lung Injury Caused by Lipopolysaccharide in Mice[J];Guiding Journal of TCM;2006-08
5 WANG He-mei,HUANG Chun-qian,ZHANG Xian-cheng,QU Wen-sheng,SUN Xiao-hong, DING Ri-gao,RUAN Jin-xiu(National Beijing Center for Drug Safety Evaluation and Research,Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China);The time-course effect of perfluoroisobutylene inhalation on endogenous nitric oxide and its synthases activity in rats[J];Bulletin of the Academy of Military Medical Sciences;2010-06
6 CHENG Shu bang, HONG JIAN qing, SHEN Mao xing (Department of General Surgery,The Second Affiliated Hospital of Jiangxi Medical College, Nanchang 330006,China);The Study on Nitric Oxide Increase Injury of Rabbit Liver during Ischemia-Reperfusion[J];Acta Academiae Medicinae Jiangxi;2001-04
7 LI Bin-lin,ZHANG Jin,LI Na,TONG Dong-yi(Department of Anesthesiology,Shengjing Hospital of China Medical University,Shenyang 110004,China);Effect of different concentrations of etomidate on the tone of isolated rabbit pulmonary and aortic artery rings before and after LPS incubation[J];Practical Pharmacy and Clinical Remedies;2012-02
8 GU Zhen Yong, LING Yi Ling , LI Shu Jin, MENG Ai Hong, ZHANG Jun Lan (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017);Properties of peroxynitrite-induced relaxation in rabbit pulmonary artery in vitro[J];Acta Physiological Sinica;2001-04
9 MENG Ai-Hong, LING Yi-Ling *, WANG Dian-Hua, GU Zhen-Yong, LI Shu-Jin, ZHU Tie-Nian (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017);Role of nitric oxide in cholecystokinin-octapeptide alleviation of tumor necrosis factor-alpha induced changes in rabbit pulmonary arterial reactivity[J];Acta Physiological Sinica;2001-06
10 DUAN Guo-Chen, LING Yi-Ling *, GU Zhen-Yong, WEI Peng, NIU Zhi-Yun, YANG Shi-FangDepartment of Pathophysiology, Hebei Medical University, Shijiazhuang 050017;Effects of cholecystokinin-octapeptide on the tension of pulmonary artery in rabbits with endotoxic shock[J];Acta Physiological Sinica;2003-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 CUI Yan Nan, MA Yu Wen, DU Jun Bao (Department of Pediatrics, the First Hospital, Beijing Medical University, Beijing 100034);A study on endothelial nitric oxide synthase in pulmonary arteries of hypoxic pulmonary hypertensive rats[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1999-06
2 QI Jian Guang 1, DU Jun Bao 1, GUO Zhi Liang 1, ZHAO Bin 2, ZHANG Qin You 1,ZENG He Ping 1, TANG Chao Shu (1 Department of Pediatrics, 3. Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China; 2;L-arginine regulates hypoxic pulmonary vascular structural remodeling and pulmonary artery smooth muscle cell apoptosis in rats[J];Journal of Beijing Medical University;2001-04
3 TIAN Hong 1, DU Jun Bao 1△ , ZHAO Wei Hong 2, TANG Chao Shu 3 (1.Department of Pediatrics, 2. Maternal and Child Health Center, 3. Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China );Influence by nitric oxide on expression of HO-1 mRNA in pulmonary artery smooth muscle cells[J];Journal of Beijing Medical University;2002-03
4 QI Jian Guang #, DU Jun Bao, JIA Jian Feng, ZHAO Bin, ZHANG Qian Jin, LI Wan Zhen (#Department of Pediatrics, the First Hospital, Beijing Medical University, Beijing 100034);The changes in pulmonary vascular structure and plasma level of nitric oxide in hypoxic pulmonary hypertensive rats[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1999-04
5 LI Zhi-Bin,LI Zhi-Chao,YAN Zhi-Qiang,SONG Jing-Chun,ZHAO Peng-Tao Department of Pathophysiology,School of Basic Medicine,Fourth Military Medical University,Xi'an 710033,China;Therapeutic effect of ANP on pulmonary microvascular endothelial cells injury induced by LPS[J];Journal of The Fourth Military Medical University;2005-04
6 MA Li-Qin, GU Zhen-Yong, DONG Guo-Kai, LI Na, GAO Feng, LIU Xia, MA Chun-Ling, CONG Bin, LING Yi-Ling Department of Forensic Medicine and Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China;Effect of cholecystokinin octapeptide on LPS-induced SOD mRNA expression and increase of NF-κB activity in rat vascular smooth muscle cells induced by LPS[J];Journal of the Fourth Military Medical University;2006-20
7 CHEN Rui fen 1,ZHOU Guang de 2,CAO Wen jun 1,WANG Min 3 (1 Department of Pathology, Capital University of Medical Sciences,Beijing 100054, China; 2 The 302nd Hospital of PLA; 3 The Department of Electron Microscopy, Capital University of Medical;Pathomorphological observation of experimental pulmonary hypertension induced by monocrotaline[J];Journal of Chinese Electron Microscopy Society;2002-01
8 LIU Shui - ping, CHEN Yu - chuan, GUO Wei, et al.( Department of Forensic Pathology, Sun Yat - sen University of Medical Sciences, Guangzhou, Guangdong, 510080, China);The Changes of Electrocardiogram and Cardiac ET -1, ANP and the Levels of Serum CK, CK -MB and cTnl in Early Phase of Crush in Jury Rats[J];Journal of Hubei Institute For Nationalities Medical Edition;2002-04
9 LI Ge, LU Jun-bao Faculty of Forensic Medicine of Sun Yat-Sen University of Medical Sciences, Guangzhou 510080 ZHANG Chun-lin Department of Orthopaedics, The First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080;Extensive soft tissue injuries-crush syndrome[J];THE JOURNAL OF LAW AND MEDICINE;2000-03
10 LIU Shui-ping, CHEN Yu-chuan,GUO Wei,et al.(Department of Forensic Pathology ,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080);The preliminary study on change of serum enzyme level in crush syndrome rat[J];Journal of Forersic Medicine;2001-04
【Secondary References】
Chinese Journal Full-text Database 6 Hits
1 CHEN Qiu-xing,LV De-chao,CAO Bin,et al.Department of Emergency Surgery,Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001,China;Study on risk factors of severe pancreatitis complicated with lung injury[J];Journal of Hepatopancreatobiliary Surgery;2012-06
2 ZHANG Jianwu, XING Zhiwei.Provincial Chest Hospital,Shijiazhuang 050041,China;Effect of HO-1 protein on CD_(54) expression in mice with acute lung injury[J];Hebei Medical Journal;2010-14
3 FAN Wei-tang,SUN Xiao-feng(The First Affiliated Hospital Guangzhou University of TCM,Guangzhou 510405,China);Changes of cytosolic calcium after acute lung injury in neonatal rats[J];Jilin Medical Journal;2012-16
4 MENG Ai-hong,WANG Bao-fa,YUAN Ya-dong,et al.Department of Respiratory Medicine,the Second Hospital of Hebei Medical University,Shijiazhuang 050017,China;Clinical Analysis of 14 Cases with Acute Drug-induced Lung Injury[J];Chinese General Practice;2009-20
5 GAO Chuan-shu,et al.Emergency Department,AnhuiProvincial Hospital,Hefei,Anhui 230000,the P.R.China.;Predictive value of serum calcium ion concentration,serum albumin concentration and blood hematocritof severe acute pancreatitis complicated acute lung injury[J];Journal of Qiqihar University of Medicine;2013-08
6 ZHANG Hai-feng,ZHANG Ying,REN Qing-ai First Department of Comprehensive Surgery,South Building,General Hospital of PLA,Beijing 100853,China;Protective effect of FK506 on the lung mitochondrial damage following traumatic stress of amputation in rats[J];Journal of China-Japan Friendship Hospital;2012-03
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Wang Junxia Wan Mei Cong Bin Ling YilingDepartment of Molecular Biology;APPLICATION OF DIG LABELED cDNA PROBE TO DETECT INDUCED NITRIC OXIDE SYNTHETASE GENE EXPRESSION OF LUNG[J];JOURNAL OF HEBEI MEDICAL UNIVERSITY;1998-01
2 GU Zhen Yong (Department of Pathophysiology, Hebei Medical University, [WT5”BZ]Shijiazhuang 050017) [WT5HZ];Peroxynitrite-Mediated Pulmonary Vascular Injury Induced by Endotoxin and the Protective Role of Cholecystokinin[J];Progress In Physiological Sciences;2001-02
3 MENG Ai Hong, LING Yi Ling *, ZHAO Xiao Yun, ZHANG Jun Lan, WANG Qiu Hong Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017;Inhibitory effect of cholecystokinin-octapeptide on production of cytokines in the lung of endotoxic shock rats[J];Acta Physiological Sinica;2002-02
4 LING YI-LING AND SHAN-SHENG(Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017)WANG LE-FENG,ZHANG JUN-LAN WAN MEI AND HAO RONG-LI;CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8)REVERSES EXPERIMENTAL ENDOTOXIN SHOCK[J];ACTA PHYSIOLOGICA SINICA;1996-04
5 WANMEI, LINGYI LING, GUZHEN YOUNG, ZHANGJUN LUAN, HUANGSHAN SHENG (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017);EFFECTS OF ENDOGENOUS NITRIC OXIDE ON PULMONARY ARTERY HYPERTENSION AND LUNG INJURY INDUCED BY ENDOTOXIN[J];ACTA PHYSIOLOGICA SINICA;1999-01
6 LI Shu-jin 1, LING Yi-ling 1, WANG Dian-hua 1, GU Zhen-yong 1, MENG Ai-hong 1, ZHU Tie-nian 1, HE Ying 2 (? 1?Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China; ? 2?Department of Endocrinology, Beijing Army G;Effects of cholecystokinin octapeptide on changes in rabbit thoracic aortic reactivities induced by lipopolysaccharides in vitro[J];Chinese Journal of Pathophysiology;2001-11
7 Wang Le-Feng; Lin YI-Lin; Huang Shan-Sheng; Wlang Hian-Ge(Department of Pathophysiology, Hebei Medical College, Shijiazhuang (050017));Clearance of substance P(SP) and vasoactive intestinal peptide(VIP) by lung during SMAO shock in rabbit[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1996-01
8 Wang Le一Feng; Ling Yi一Ling;Huang Shan一Sheng; Zhang Jun一Lan;Wang Mei;Hao Rong一Li(Department of Pathophysioloyg,Hebei Medical Universrty,Shijiazhuang(050017);Clearance of cholecystokinin(CCK)by lung during normal and endotoxic shock[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1996-06
9 Ling Yi-Ling,Huang Shan-Sheng,Zhang Jun-Lan,Wan Mei,Hao Rong-LiDepartment of Pathophysiology,Hebei Medical University,Shijiazhuang(050017);Effect of cholecystokinin on SOD、MDA contents and phagocyte chemiluminescence of reversing endotoxin shock rat[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1997-05
10 GU Zhen-Yong, LING Yi-Ling, MENG Ai-Hong, CONG Bin, HUANG Shan-Sheng Department of Pathophysiology, Hebei Medical University, Shijiazhuang(050017);Effects of cholecystokinin octapeptide on the response of rabbit pulomonary artery induced by LPS in vitro[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1999-06
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