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《Acta Physiologica Sinica》 2012-04
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Effects of carnitine on respiratory chain and metabolism of oxygen radical in mitochondria of liver after exhaustive running in training rat

LI Jie *,CHEN Li College of Physical Education,Northwest Normal University,Lanzhou 730070,China  
The aim of the present study was to investigate the effect of carnitine on cellular respiratory chain and metabolism of oxygen radical in mitochondria of liver after exhaustive running in training rats.Forty male Wistar rats were randomly divided into 4 groups(n=10):control,carnitine,training and training+carnitine groups.The training and training+carnitine groups received 6-week treadmill training,whereas carnitine and training+carnitine groups were administrated intragastrically with carnitine(300 mg/kg per d) for 6 weeks.After exhaustive running,all the groups were sacrificed to obtain liver samples,and liver mitochondria were extracted by differential centrifugation.Spectrophotometric analysis was used to evaluate activities of respiratory chain complexes(RCC) I-IV,superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) and the content of malondialdehyde(MDA) in the liver mitochondria.The results showed that,compared with the control group,the carnitine group exhibited increased RCCIV activity(P0.05),the training group exhibited increased RCCI,RCCIII and RCCIV activities,and the training+carnitine group showed increased RCCI-IV activities(P0.05 or P0.01).Moreover,RCCI and RCCIV activities in the training+carnitine group were higher than those in the carnitine and training groups(P0.05 or P0.01).Compared with the control group,the training+carnitine group showed increasedSOD activity(P0.01),the carnitine,training and training+carnitine groups showed increased GSH-Px activities(P0.05,P0.01),and the training and training+carnitine groups showed decreased MDA contents(P0.05,P0.01).The training+carnitine group showed increased GSH-Px activity compared to that in the carnitine group(P0.01).The SOD activity in the training+carnitine group was higher than those in the carnitine and training groups(P0.05 or P0.01),and the MDA level in the the training+carnitine group was lower than those in the carnitine and training groups(P0.01).These results suggest that training and carnitine can increase the function of respiratory chain and antioxidant capacity in liver mitochondria,and the improving effects of training and carnitine can be synergistic.
【Fund】: supported by the National Natural Science Foundation of China (No. 31060145);; the Natural Science Foundation of Gansu Province China (No. 1107RJZA087)
【CateGory Index】: R87
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