Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《ACTA PHYSIOLOGICA SINICA》 1996-04
Add to Favorite Get Latest Update

ENDOTHELIN- STIMULATED PROLIFERATION OF THORACIC ARTERY SMOOTH MUSCLE CELLS INVOLVES ACTIVATION OF MITOGEN-ACTIVATED PROTEIN KINASE

LI TIAN-CHANG; TONG LI-JIA; PANG YONG-ZHENG; LIU XIU-HUA; WANG XUE-QING; HU DA-YI AND TANG CHAO-SHU (Heart Center of Beijing Red Cross Chaoyang Hospital, Beijing 100020;Beijing Medical University, Institute of Cardiovascular Research, Beijing 100083)  
Endothelin (ET) is a potent vasoconstrictor whose responses are mediated through a common G-protein coupled receptor. So far little is known concerning its potential mitogenic capacity. In the present study, experiments were conducted to determine the role of mitogen-activated protein kinase (MAPK) activation in the rabbit thoracic artery smooth muscle cells (VSMC) in response to stimulation by ET-1. It was found that ET-1 produced concentration- and time-dependent increases in 3H-TdR incorporation and in MAPK activity of these cells. All the increases were inhibited by protein kinase C (PKC) inhibitors, such as Staurosporine (STP) and H-7 and by ETA receptor antagonist BQ123, but not by specific tyrosine kinase inhibitor Herbimycin A (Herb). Pretreatment with PKC activator PMA (phorbol myristate acetate) for 24 h (PKC downregulation) significantly attenuated ET-1-induced MAPK activation. These results indicate that: (1) ET-1-stimulated proliferation of VSMC involves the activation of MAPK and (2) ET-1-induced MAPK activation is mediated through ETA receptor and PKC.
【CateGory Index】: R331.33
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 8 Hits
1 XUE Lin1,PAN Chun-Shui1,ZHAO Jing1,ZHAO Chun-Yu2,TANG Chao-Shu2,and QI Yong-Fen1,2(1.Department of Cadiology,First Hospital of Beijing University,Beijing 100034;2.Key Laboratory of Molecular Cardiovascular Science,Beijing 100083,China);Adrenomedullin with Its Receptor Inhibit the Proliferation of Vascular Smooth Muscle Cells in Rats Induced by Lysophosphatidic Acide[J];中国动脉硬化杂志;2008-01
2 Fan Chunyan1,Song Jinxiang1,Qiao Jian2,Liu Wenju2,Wang Huiyu2,Wang Jianlin2,Zou Sumei2 (1.College of Agriculture,Hebei Engineering University,Handan,Hebei 056021; 2.College of Veterinary Medicine,China Agricultural University,Beijing 100094);BQ123 Inhibited The Muscularization of Nonmuscular Pulmonary Artery Induced by Low Ambient Temperature in Broiler[J];中国家禽;2007-02
3 FAN Chun-yan, QIAO Jian *, ZHAO Li-hong, LIU Wen-ju, OU De-yuan,YANG Ying, GAO Ming-yu(College of Veterinary Medicine,China Agricultural University,Beijing 100094,China);Effect of BQ123 on Pulmonary Vascular Remodeling in Low-temperature-induced Broiler Chickens[J];畜牧兽医学报;2005-06
4 YUAN Jie, LI Ju-xiang, ZHENG Xian-ke, et al. (Department of Physiology, Yunyang Medical College, shiyan, 442000, Hubei, China);Effects of L-arginine and Taurine on Proliferation of Vascular Smooth Muscle Cells Induced by Lysophosphatidic Acid[J];郧阳医学院学报;2002-04
5 WAHG Xiao Hong, OU He Sheng, FU Min Gui, LI Shu Lian, PANG Yong Zheng, TANG Chao Shu, LIU Nai Kui 1 (Institute of Cardiovascular Research, The First hospital, 1Institute of Cardiovasclar Basic Research, Beijing Medical University, Beijing;The effect of liposome encapsulated C type natriuretic peptide on vascular response[J];中国药理学通报;1999-05
6 WANG Xiao-Hong,SU Jia-Lin,LI Xia,AN Guo-Shun,AN Song-Zhu, TANG Jian,TANG Chao-Shu,WANG Shu-Heng,LIU Nai-Kui Institute of Cardiovascular Basic Research,Beijing Medical University,Beijing(100083);Adrenomedullin inhibits the lysophosphatidic acid-induced proliferation of vascular smooth muscle cells[J];中国病理生理杂志;1999-04
7 Xia Bing 1, Cui Ruiyao 1, Wang Xiaohong 1, Su Jialin 2, Li Xia 2, Tang Chaoshu 2 (1. Department of Pathophysiology of Medical College of Qingdao University\ 2. Cardiovascular Institute of Beijing Medical University);Role of Endothelin in Hypertensive Myocardial Hypertrophy of Rats[J];高血压杂志;1997-03
8 LiTianchang1,TianQing2,ZhaoDong1,LiQianhong1,QiuJingxin1,Zhao Yuntao2,ChangJaw┐ Kang2,SuJingyi1,TangJian1,TangChaoshu1(1.CardiovascularInstituteofBei jingMedicalUniversity,Beijing1000832.PhoenixPharmaceuticals,IncUSA,CA 94002-40413.NavyGeneralHospita;AdrenomedulinInhibitstheET-inducedProliferationofVascularSmoothMuscle Cels[J];高血压杂志;1996-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Yang Ying, Wu Zhenlong, Zhang Jianjun, Sun Maohong, Dong Shishan, Gao Mingyu, Ou Deyuan, Fan Chunyan, Liu Wenju, Tian Yong, Qiao Jian (College of Veterinary Medicine, China Agricultural University, Beijing 100094, China);Preventive effect of endothelin receptor antagonist BQ123 on pulmonary hypertension induced by low ambient temperature in broilers[J];中国农业大学学报;2005-03
2 FAN Chun-yan, QIAO Jian *, ZHAO Li-hong, LIU Wen-ju, OU De-yuan,YANG Ying, GAO Ming-yu(College of Veterinary Medicine,China Agricultural University,Beijing 100094,China);Effect of BQ123 on Pulmonary Vascular Remodeling in Low-temperature-induced Broiler Chickens[J];畜牧兽医学报;2005-06
3 LIU Wen-ju, QIAO Jian~*, OU De-yuan, FAN Chun-yan, YANG Ying, LI Jing, GAO Ming-yu(College of Veterinary Medicine, China Agricultural University,Beijing 100094,China);Effects of Two Histamine Receptor Antagonists on Pulmonary Hypertension in Broiler Chickens[J];畜牧兽医学报;2005-04
4 OU De-yuan, QIAO Jian~*, LIU Wen-ju, YANG Ying, FAN Chun-yan, GAO Ming-yu, DONG Shi-shan(College of Veterinary Medicine, China Agricultural University, Beijing 100094,China);Effect of Zafirlukast on Pulmonary Hypertension in Broiler Chickens[J];畜牧兽医学报;2005-02
5 REN Yongsheng 1▲ , PAN Chunshui 1 ,WU Qizhuan 2,PANG Yongzheng 1,TANG Chaoshu 1,3 ,QI Yongfen 3△ (1. Institute of Cardiovascular Diseases Research, 2. Neural Medicine,Peking University First Hospital, Beijing 100034,China;3. Department of Physiology, Peking University School of Basic Medical Sciences);Involvement of endothelin in the proliferative effect of lysophosphatidic acid on vascular smooth muscle cells in rats[J];北京大学学报(医学版);2003-05
6 QI Yong-fen, XIA Chun-fang, CHEN Ya-hong, XUE Lin, PANG Yong-zheng, TANG Chao-shu (Institute of Cardiovascular Research, the First Hospital, Peking University, Beijing 100034, China);Effects of adrenomedullin on proliferation of vascular smooth muscle cells induced by urotensin Ⅱ[J];中国病理生理杂志;2002-03
7 Xiang Ruiping,Wang Xiaolong,Wang Jinyong and Li Jiakui (College of Veterinary Medicine,Nanjing Agric Univ,Nanjing 210095,China);Muscularization of pulmonary arterioles in field cases of broilers with pulmonary hypertension syndrome[J];南京农业大学学报;2001-01
8 MA Jian ,YANG Ye, LI Zai-quan, et al (Navy 401 Hospital ,Qingdao 266071,China);Effect of proadrenomedullin on proliferation of vascullar smooth muscle cells induced by Ang Ⅱ[J];基础医学与临床;2000-06
9 WT5BZ]Dong Shishan,Qiao Jian,Li Shaowen,Qiao Huili,Chen Shouqiang,Ge Zhaohui (College of Veterinary Medicine,CAU,Beijing 100094);THE RELATIONSHIP BETWEEN PULMONARY HYPERTENSION AND BROILER ASCITES SYNDROME[J];畜牧兽医学报;2000-04
10 Chronic Pulm onary Hypertension Xiong Mi, Zhang Yan, Che Dongyuan etal Departm entof Pathology, Schoolof Basic MedicalSciences, TongjiMedical University, Wuhan 430030;The Relationship between Proliferation and Differentiation of Lung Vascular Pericytesand the Developm entof[J];同济医科大学学报;1999-05
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 CHAI Juan1,HU Yu-xia2,BI Shi-cheng1,TAN Xun1(1.College of Animal Sciences,Zhejiang University,Hangzhou 310058,China; 2.Zhejiang Huineng Animal Health Co.,LTD,Haining 314422,China);Role of endothelin A receptor on the proliferation of broiler pulmonary artery smooth muscle cells[J];南京农业大学学报;2012-02
2 LIN Juan*, SU Jin-zi * Cardiovascular Department, Fujian Province Official Hospital, Fuzhou 350003, China;The relationship between essential hypertension with target organ damage and serum adrenomedullin levels[J];中华高血压杂志;2011-05
3 FAN Chunyan1,2,SONG Jinxiang1,QIAO Jian2,LI Jing2,GU Chenggang3, YANG Ying2,OU Deyuan2,LIU Wenju2 (1.College of Agriculture,Hebei University of Engineering,Handan,Hebei 056021; 2.College of Animal Medicine,China Agricultural University,Beijing 100193; 3.Yangzhou Vacbio Bioengineering Co.,Ltd,Yangzhou,Jiangsu 225127);Preventive Effect of BQ123 on Ascites Syndrome in Broilers[J];中国家禽;2010-03
4 HU Peng1,LU Ling1,HU Bo1,QIN Yuan-han2(1.Dept of Pediatrics,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;2.Dept of Pediatrics,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China);C-type natriuretic peptide:an important effector molecule for renal homeostasis[J];中国药理学通报;2009-10
5 GUO Rui-Wei, HUANG Lan, SONG Ming-Bao, WANG Hong, and GAO Pan(Cardiovascular Research Institute of Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China);Effect of Stromal Interaction Molecule 1 Knockdown on Cell Cycle of Vascular Smooth Muscle Cell[J];中国动脉硬化杂志;2008-09
6 ZENG Zhe,QIU Han-ying.(Physician Department,The Second Affiliated Hospital of Shantou Medical College,Shantou 515041,China);Progress in Research on Protection Mechanisms of Taurine on Cardiaovascular System[J];医学综述;2008-06
7 XUE Lin1,PAN Chun-Shui1,ZHAO Jing1,ZHAO Chun-Yu2,TANG Chao-Shu2,and QI Yong-Fen1,2(1.Department of Cadiology,First Hospital of Beijing University,Beijing 100034;2.Key Laboratory of Molecular Cardiovascular Science,Beijing 100083,China);Adrenomedullin with Its Receptor Inhibit the Proliferation of Vascular Smooth Muscle Cells in Rats Induced by Lysophosphatidic Acide[J];中国动脉硬化杂志;2008-01
8 Song Jinxiang1,Fan Chunyan1,Qiao Jian2**,Liu Wenju2,Ou Deyuan2,Liu Ying3 (1.College of Agriculture,Hebei Engineering University,Handan,Hebei 056021; 2. College of Veterinary Medicine,China Agricultural University,Beijing 100094; 3.Luoyang Pu-like Bio-engineering Co.,Ltd,Luoyang,Henan 471000);Role of Pulmonary Vascular Remodeling in PH Induced by Low Temperature in Broiler[J];中国家禽;2007-05
9 Fan Chunyan1,Song Jinxiang1,Qiao Jian2,Liu Wenju2,Wang Huiyu2,Wang Jianlin2,Zou Sumei2 (1.College of Agriculture,Hebei Engineering University,Handan,Hebei 056021; 2.College of Veterinary Medicine,China Agricultural University,Beijing 100094);BQ123 Inhibited The Muscularization of Nonmuscular Pulmonary Artery Induced by Low Ambient Temperature in Broiler[J];中国家禽;2007-02
10 GUAN Xiao-yong BI Xiong-jie Department of Laboratory,Liuzhou Second Affiliate Hospital,Liuzhou Medical Schools,Liuzhou,Guangxi 545006,China;A comparison between C-reactive protein,adrenomedullin and endothelin-1 in patients of chronic congestive heart failure[J];中国基层医药;2006-08
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved