CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8)REVERSES EXPERIMENTAL ENDOTOXIN SHOCK
LING YI-LING AND SHAN-SHENG(Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017)WANG LE-FENG,ZHANG JUN-LAN WAN MEI AND HAO RONG-LI
The effects of CCK-8 on the mean arterial pressure (MAP),blood components and path-morphological changes during endotoxin shock (endotoxin, 8mg/kg b,w. iv.)in rats,as well as on the 24 h mortality rate (MR) of the lead-sensitized rats in endotoxin shock (endotoxin 1μg/100g b.w.iv.)were observed.The results showed that injection of CCK in ES rats led to an increase in MAP,and a reduction of hematocrit and platelet as well as white cell count;the mortality rae decreased and the lesion in main organs lessened.it is suggested that release of endogenous CCK has important protective action during endotoxin shock.