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《Journal of Mathematical Medicine》 2005-06
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Antagonistic Effects of Organic Extracts of Hawthorn Fruit on Chromium(Ⅵ)-induced Mutation in Human Peripheral Blood Lymphocytes

Li Hongzhi,et al(College of Basic,GuangDong pharmaceutical college,Guangzhou 510224)  
Objective: To study the antagonistic effect of organic extracts of Hawthorn Fruit on chromium(Ⅵ)-induced mutation.Methods: Using unscheduled DNA synthesis(UDS) assay,the effects of 0.03 g/ml, 0.015 g/ml and 0.0075g/ml organic extracts of Hawthorn Fruit on UDS induced by potassium bichromate 0.31μg /ml chromium(Ⅵ) in human peripheral blood lymphocytes were determined.The effects of the order of adding organic extract of Hawthorn Fruit and potassium bichromate into cultured lymphocyte suspension on UDS were observed at the same time.Results: The value of CPM revealed a significantly higher level in positive control group exposed to 0.31μg /ml chromium(Ⅵ) compared with that in negative control group exposed to distilled water(P0.01).In the comparative experiments with different methods for adding the substances to be tested : simultaneously adding the organic extracts of Hawthorn Fruit and potassium chromate into the cultured lymphocyte suspension,and adding the organic extracts of Hawthorn Fruit first and potassium chromate afterward or in turn at intervals of 2 hours, the values of CPM revealed a significant negative correlation with the exposure levels of organic extracts of Hawthorn Fruit(P0.01),and each value of CPM in all Hawthorn Fruit groups was significantly lower than that of positive control group.Conclusion: Hawthorn Fruit revealed significant antimutagenic effect on chromium(Ⅵ).
【CateGory Index】: R285;
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