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《Journal of Mathematical Medicine》 2008-05
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Orthogonal Experimental Design in 17α-hydroxy-21-iodine Progesterone Improved Synthesis of the Application

Xie Heqing,et al(Faulty of Life Science,Huzhou Teachers College,Huzhou 313000)  
Objective: to hydroxy-progesterone and an iodine chloride synthesized from 17 α-hydroxy-21-iodine progesterone.Method: inspection system solvent,temperature and the ratio of raw materials affected the outcome of the reaction,has been optimized conditions by orthogonal design.Results: the adoption of new methods of synthesis of the target product.Conclusion: The best conditions are as follows: reaction solvent for the water,the reaction temperature is 0~5 ℃,hydroxy-progesterone with a molar ratio of iodine chloride 1.0:1.0,after refining crude yield more than 98 percent.
【CateGory Index】: TQ463.2
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