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《Chemistry of Life》 2010-01
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Application of intron in bioinformatics researches and transgenic engineering

Bing Chen,Jian-Fan Wen 1State Key Laboratory of Genetic Resources and Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650223,China;2Graduate School of the Chinese Academy of Sciences,Beijing 100039,China  
Intron is widespread in eukaryotic genomes.It is already known that intron is an important regulation factor of eukaryotic gene expression and is involved in gene evolution.Although the functions of intron are not very clear so far,and its origin and evolution is still a debatable issue,knowledge of intron has been applied in bioinformatic analysis and genetic engineering.In this paper,the application strategies in genomic analysis,molecular evolution and phylogenetic analysis,and transgenic engineering of this important gene structural element were reviewed.
【Fund】: 国家基金委项目(30021004 30623007);; 科技部“973”项目(2007CB815705)资助
【CateGory Index】: Q811
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