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《Chemistry of Life》 2010-04
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Application of RBL-2H3 cell line in allergic diseases

Ping Chen,Lin-Hua Fang Shandong Provincial Hospital,Shandong University,Jinan 250012,China  
Mast cells play a pivotal role in the development of allergic diseases.The RBL-2H3(rat basophilic leukemia) cell line,although as a subline of rat basophilic leukemia cell line(RBL),resembles some characteristics of mast cells and is commonly used as an in vitro cell line in the allergy research.The RBL-2H3 cell line is widely used to the studies on the functions of mast cells and its activation mechanisms.Besides,RBL cell line is regarded as a suitable model in antigen-specific IgE measurement.This review will focus on the application of RBL-2H3 cell line in many aspects of allergic diseases and anticipate its prospect.
【CateGory Index】: R593
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