Role of anti-adhesion immunotherapy in severe acute respiratory syndrome associated acute lung injury
SUN Gui-Zhi, LI Xiao, ZHOU Tong, ZHANG Dong-Qing, DENG Wei-Wu, CHEN Nan ( Rui Jin Hospital, Shanghai Second Medical University, Shanghai 200025, China; Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China)
Severe acute respiratory syndrome(SARS) , known as acute respiratory contagion, can induce lung injury relating to acute respiratory distress syndrome(ARDS) in earlier period, and lung fibrosis in later period. During its progression, there has been immune defence overactivity followed by leukocytic immune damage. Adhesion molecules mediating cell-cell adhesion plays a key role in SARS acute lung injury. The lung injury might be reduced by blocking the overactivated immune defence reaction and leukocytic adhesion cascades with anti-adhesion immunotherapy in earlier stage of this disease.
【CateGory Index】： R511.9