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《Chinese Bulletin of Life Sciences》 2006-05
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Advances of digit ratios in human

LU Hong, HUO Zheng-Hao* (Department of Medical Genetics and Cell Biology, Ningxia Medical College, Yinchuan 750004, China)  
Digit ratios were fixed early in pregnancy and showed sex differences, males have lower values of digit ratios than do females. 2D∶4D ratios is negatively related to testosterone levels and sperm counts and positively related to oestrogen level. The formation of digit ratios and differentiation of gonads are determined by HOXA and HOXD. Digit ratios have been found to correlate with autism, dyslexia, migraine, stammering, immune dysfunction, myocardial infarction and breast cancer. It indicates that digit rations in Humans may be used in diagnosis, prognosis of diseases as a predictor, such as myocardial infarction and breast cancer.
【Fund】: 国家自然科学基金项目(30260045);; 宁夏高等学校科学技术研究项目(JC200504)
【CateGory Index】: Q983
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