Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Life Science Research》 2018-01
Add to Favorite Get Latest Update

An Analysis of Differentially Expressed Genes in Dopaminergic Neurons in Parkinson's Disease

LUO Dong-hui;LUO Kun;LIU Hong-de;Department of Neurology, the First Affiliated Hospital of Xinjiang Medical University;Department of Neurosurgery, Xinjiang Evidence-based Medicine Research Institute, the First Affiliated Hospital of Xinjiang Medical University;State Key Laboratory of Bioelectronics, School of Biological Science &Medical Engineering, Southeast University;  
Parkinson's disease(PD) is a common neurodegenerative disease, affecting a vast population. Here,the data involving both gene expression and DNA methylation were analyzed from dopaminergic cells in PD.Genes with different expression levels or DNA methylation levels were identified, and a correlation between those genes and PD was revealed. Genes associated with formation and elongation of microtubule, including SLAIN1, TAGLN3 and TUBB2 B, were up-regulated, whereas those related to innate immune system, such as LY96, were down-regulated. Surprisingly, SCG5, which is involved in immune response for PD, was upregulated. In addition, DNA methylation was found to be highly activated near the transcription start sites.Besides its function in gene transcription, DNA methylation with a high level may cause conformational changes of chromatin structure through affecting PRC1 and Pc G complexes. Moreover, those genes may be involved in regulation of axon guidance, neuronal differentiation, migration, intracellular trafficking and other functions. The results provide new insights into better understanding of molecular mechanisms in PD.
【Fund】: 新疆维吾尔自治区自然科学基金面上项目(2015211C057)
【CateGory Index】: R742.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved