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《Life Science Research》 2018-01
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The Role of Sodium Channels in Insulin Secretion in Pancreatic β Cells

CHEN Chong;WEI Shan-shan;WANG Song-hua;YAO Li-hua;School of Life Science, Jiangxi Science & Technology Normal University;Institute of Organic Functional Molecules, Jiangxi Science & Technology Normal University;  
Pancreatic islet β cells are typical excitable endocrine cells that secrete insulin in response to increased glucose levels. Functional failure in β cells probably results in variety of diseases, particularly diabetes mellitus(DM). There has been growing research interest in insulin secretion and regulation of pancre-atic β cells, especially in the ion channels, such as K~+ and Ca~(2+) channels. However, less research has been done on Na~+ channels, a kind of cation channels widely distributed in the cell membrane with multitudinous subtypes. These channels have proven to have a variety of physiological functions via participating in action potential formation, substance transportation and intercellular communication and so on. Here, the subtypes,physiological characteristics and functions of Na~+ channels are reviewed to offer new insights for the research related to pancreatic β cells.
【Fund】: 国家自然科学基金资助项目(31660275 81360205);; 江西省杰出青年人才资助项目(20171BCB23077);; 江西省教育厅科技项目(GJJ150792 GJJ160778)
【CateGory Index】: R587.1
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