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《Chinese Journal of Industrial Medicine》 2005-05
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Effects of inhaled perfluoroisobutylene on sulfhydryls in the lung tissues of mice

ZHAO Jian,ZHANG Tian-hong,DING Ri-gao,ZHANG Xian-cheng,HUANG Chun-qian,SUN Xiao-hong(Institute of Pharmacology and Toxicology,Academy of Military Medical Science,Beijing 100850,China)  
Objective To investigate the changes of sulfhydryls(SH)in acute lung injury(ALI)in mice induced by inhalation of perfluoroisobutylene(PFIB).Method Mice were exposed to gaseous PFIB for 5 minutes in a flow-past whole-body exposure system.The changes of total sulfhydryls(TSH),nonprotein sulfhydryl(NPSH)and protein sulfhydryl(PSH)in the lung tissues were assayed by Ellman's reagent method.Result Level of NPSH,mainly reduced gluthathion,elevated significantly in the lung tissues of mice from 4h to 24h after ALI induced by PFIB inhalation,as compared to that in normal mice.Conclusion Oxidative damage may not play a pivotal role in mouse ALI induced by PFIB inhalation.
【Fund】: 军事医学科学院创新基金
【CateGory Index】: R595
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