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《Medical Journal of Qilu》 2001-01
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THERAPEUTIC EFFECT OF DIFFERENT DOSAGE OF NALOXONE IN ACUTE CEREBRAL INFARCTION

ZHANG Shunkai,PAN Guangqiang, YI Xingyang, et al Department of Neurology, Ruian People's Hospital, Ruian 325200, Zhejiang  
Objective To study the clinical therapeutic effect and safety of different-dosage naloxone in acute cerebral infarction(ACI). Methods 120 cases of ACI were randomly divided into two groups: naloxone-treating group and the control group(given venoratone). The naloxone-treating group was then randomly subdivided into high-dosage group and low-dosage group. According to the defect grade of nervous function, we judged the curative effect on the different therapies. Results The effective rate in the high-dosage naloxone-treating group was significantly superior to that in the control group(μ= 2.163, P0. 05). There was no apparent side effects during the treatment. There was no marked difference between the low-dosage naloxonetreating group and the control group(μ= 0.726, P0.05). The therapeutic effect of the high-dosage naloxone given within 48 hours was significantly superior to that after 48 hours (t=2.473, P0.05 ). Conclusion High-dosage of naloxone is effective and safe in the treatment of ACI. The use of naloxone is better in the early stage.
【CateGory Index】: R743.33
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【References】
Chinese Journal Full-text Database 2 Hits
1 LI Jun Xi Qiao People's Hospital of Foshan,Foshan 528211, China;The clinical observation of naloxone combined with low-molecular-weight haparin calcium in treating acute cerebral infarction[J];Acta Medicinae Sinica;2005-03
2 HAN Shuanren. Department of Neurology, Taiyuan Central Hospital, Shanxi, Taiyuan 030009,China;The therapeutic effect of naloxone on treating acute cerebral infarction of large area[J];Journal of Diffcult and Complicated Cases;2003-02
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Guo Yupu, et al (PUMC Hospital, Beijing);Ultrastructural Observation of Acute Cerebral Ischemia Pathological Changes after Carotid Ligation in Rats[J];Acta Academiae Medicinae Sinicae;1990-02
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 YANG Yong-sen,TAO Xia,ZHONG Ze-qing,et al.Center of Difficult and Complicated Disease,Affiliated Taihe Hospital of Yunyang Medical College,Hubei,Shiyan 442000,China;Relationship between the dosage and efficiency of naloxone in the treatment of acute cerebral infarction[J];Chinese Journal of Difficult and Complicated Cases;2006-06
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