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《Science and Technology of Food Industry》 2012-05
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Study on Juglans mandshurica oil to improve learning and memory ability of mice

XU Hong-yan1,2,BAO Yi-hong1,*,LIU Fu-guo1,YU Yang-yang1(1.Forestry College of Northeast Forestry University,Harbin 150040,China;2.Agricultural College of Yanbian University,Yanji 133000,China)  
To investigate the effect of Juglans mandshurica oil(JMO) from northeastern on improving learning and memory in mice.Forty male KM mice were randomly divided into four groups:control group,JMO low dose group,JMO middle dose group and JMO high dose group respectively.Mice in control group were given physiological saline,and mice were given 5mL/(kg bw·d)by gavage in JMO low dose group,mice were given 10mL/(kg bw·d)by gavage in JMO middle dose group,and mice were given 20mL/(kg bw·d)by gavage in JMO high dose group for 30 days.Jumping platform experiment and water maze experiment were started on the thirty-first day.Latent period of mice on passive avoidance response in JMO groups obviously extended,compared with control group,difference of middle dose group was significant(P0.05),and arrived time to the end and error numbers obviously decreased,compared with control group,difference of middle dose group was significant(P0.05).Results showed that JMO could increase the capability of learning and memory on passive avoidance response in jumping platform experiment and space identification in water maze experiment,and significantly possess the effect of improving learning and memory in mice.
【Fund】: 中央高校专项基金(LD09C14)
【CateGory Index】: R151
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