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Anti-fatigue effects of rosavin extracted from Rhodiola rosea L.

ZHANG Hui-yun1,MA Chao-yang1,*,WANG Hong-xin1,2 (1.School of Food Science and Technology,Jiangnan University,Wuxi 214122,China; 2.State Key Laboratory of Food Science and Technology,Wuxi 214122,China)  
Objective:To study the anti-fatigue effects of rosavin extracted from Rhodiola rosea L. in mice. Methods:The mice were randomly divided into five groups including the control group administered with physiological saline,three rosavin groups administered with doses of 60,180,360mg/kg mb rosavin and salidroside group(180mg/kg mb) for 30 consecutive days,respectively. And the level of muscle lactate,liver and muscle glycogen,serum urea nitrogen and the exhaustive swimming time were determined after swimming test. Results:Compared with control group,different doses of rosavin significantly extended the swimming time(p0.05) and increased the contents of liver(p0.05)and muscle glycogen,while reducing that of lactate in muscle significantly(p0.05). Salidroside was slightly better than rosavin in the anti-fatigue effects of the same dose. But there was no significant difference in rosavin and salidroside(p0.05). Conclusion:rosavin had anti-fatigue effect on mice.
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