Hypertension Lowering Study on L-nitro-arginine Hypertension Model Rats by Monascus Administration
TANG Fen-fang1,ZHANG Jing1,ZOU Jie1,SUN Wei1,JIAO Xiao-hui2,JIN Zong-lian1(1.College of Arts and Sciences of Beijing Union University, Beijing 100083, China;2.Capital University ofMedical Sciences, Beijing 100054, China)
The purpose of the Study was to investigate the effect of monascus on lowering hypertension and the changes ofplasma endothelin (ET) value and calcitonin gene-related peptide(CGRP)value in L-nitro-arginine(L-NNA)hypertension modelrats. There were 20 male Wistar rats divided into 3 groups:control group(group C)8 cases,L-NNA hypertension group(groupL)6 cases and L-NNA+monascus group(group L+M)6 cases. The results showed ET and ET/CGRP were increased markedlyin L-NNA hypertension model rats(p0.05), while CGRP showed no significant difference between group C and group L(p=0.8342).ET was reduced remarkably in L+M group(p0.001).Therefore,increasing ET and ET/CGRP might lead to thehypertension of rats. Monascus could lower hypertension by reducing blood ET value.
【CateGory Index】： R285