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《Food Science》 2008-08
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Toxicity Study and Safety Assessment of Wheat Bran Peptide

CAO Xiang-yu1,2,LIU Jian-li2,LIU Chang-jiang1,,WANG Xue1,GUO Wei-wei1(1.College of Food Science,Shenyang Agricultural University,Shenyang 110161,China;2. School of Life Science,Liaoning University,Shenyang 110036,China)  
Objective:To study the toxicity of wheat bran peptide. Methods:The Ames test,bone marrow polychromatic erythrocyte micronucleus test,spermatogonial chromosomal aberrations test and comet assay were used to detect the toxicity of wheat bran peptide. Results:The LD50 of wheat bran peptide by i.g. to mice is more than 20 g/kg,no toxicity existing. If S9 activation or not,there are all negative results of the TA97,TA98,TA100 and TA102 strains in Ames test. In bone marrow polychromatic erythrocyte micronucleus test,spermatogonial chromosomal aberrations test and comet assay,there are not significant differences between the negative control and the treated groups(p0.05) in dose of 2.5,5.0,10.0 g/kg bw respectively. The results of genetic toxicity tests are all negative in Ames test,bone marrow polychromatic erythrocyte micronucleus test,spermatogonial chromosomal aberrations test and comet assay. Conclusion:Wheat bran peptide has no toxicity.
【Fund】: 辽宁省科技厅科技攻关项目(2004205001)
【CateGory Index】: R114
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