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《Food Science》 2008-12
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Antioxidation of Stropharia rugoso-annulata Extract(SRE) on CC1_4-induced Acute Liver Injury in Mice

WANG Xiao-wei1,WANG Feng1,TAO Ming-xuan1,CHENG Guang-yu2,3,,XI Qing-li4,LU Zhong-ming4(1.Ginling College,Nanjing Normal University,Nanjing 21097,China;2.School of Life Science,Nanjing Normal University,Nanjing 210097,China;3.Jiangsu Wuzhong Nature Biotech Co. Ltd.,Nanjing 210097,China; 4.Jiangsu Centers for Diseases Prevention and Control,Nanjing 210093,China)  
Objective:This study was designed to evaluated the antioxidant effects of SRE on liver and main organs in mice with CCl4-induced acute liver injury. Methodes:The CIR mice were administered by gavage with SRE(100,200 and 400 mg/kg·d,respectively) for 30 days before the administration with a dose ofCCl4(80 mg/kg·d). The mice were sacrificed at 24 h after administration with SRE and their blood,liver,heart,kidney and spleen were collected for assaying antioxidant parameters,respectively. Results:The 400 mg/kg·d dose of SRE significantly(p0.01) lowers the serum ALT,while the hepatic activities of total SOD,Mn-SOD,Cu,Zn-SOD and GSH-Px are significantly increased(p0.01),and content of MDA is significantly(p0.01) lowered when compared with CCl4 administration group. SRE could significantly increase the activities of SOD and GSH-Px in heart and kidney,and lower the content of MDA in heart,compared with CCl4 administration group. The activities of total SOD and Mn-SOD of CCl4 administration group are compensatorily increased in spleen compared with the normal group(p0.05). After the SRE administration,these indexes are decreased to the normal levels. The component analysis of SRE indicated that polysaccharides and flavonoids may be main antioxidant components. Conclusions:SRE can be proposed to protect the liver and various tissues against CCl4-induced oxidative damage in mice.
【Fund】: 江苏省高校自然科学基础研究项目(07KJD550116)
【CateGory Index】: R285.5
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