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《Food Science》 2012-13
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Effect of Raspberry Ketone on Lipid Metabolism and Inflammatory Factors in Hyperlipidemic Rats

MENG Xian-jun,YANG Lei,LI Bin(College of Food Science,Shenyang Agricultural University,Shenyang 110866,China)  
Objective: To explore the effect of raspberry ketone(RK) on lipid metabolism and inflammatory factors in hyperlipidemic rats.Methods: Forty SD rats(half male and half female) were randomly divided into 5 groups.The rats fed normal food were served as normal control group;the rats fed high-fat diets for 4 weeks were administered with RK at the doses of 20,10 g/L and 5 g/L to create high,middle and low dose groups.The rats in each group were killed after the administration of RK for 8 week.The body weight,visceral index,and serum lipid parameters such as TC,TG,HDL-C and LDL-C,apolipoprotein including apoA-I and apoB,C-reactive protein(hs-CRP),TNF-α and IL-6 were determined.Results: RK could significantly reduce TC,TG and LDL-C levels in hyperlipidemic rats and increase HDL-C content.Meanwhile,serum apoA-I level revealed a significant elevation while apoB revealed an obvious reduction.Moreover,RK could reduce the ratio between liver and body weight,and significantly reduce serum hs-CRP,TNF-α and IL-6 contents.Conclusion: RK not only has a role in regulating blood lipids but also can modulate low inflammation state in hyperlipidemic rats.
【Fund】: 辽宁省科技厅科技攻关计划项目(2011105001);; 国家公益性行业(农业)科研专项(201103037)
【CateGory Index】: R285.5
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