Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Food Science》 2013-15
Add to Favorite Get Latest Update

Progress and Prospect of Overnutrition on Metabolism and Human Wellness

PANG Guang-chang,CHEN Qing-sen,HU Zhi-he,XIE Jun-bo(Tianjin Key Laboratory of Food Biotechnology,College of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China)  
G protein coupled receptors(GPCRs) are developed for organisms to uptake enough foods during evolution.As a primary nutrition sensor system,GPCRs are expressed in endocrine cells within the gut mucosa,and absorb nutrients and quantitate them with voltage-gated calcium channels,sodium potassium pump and vegetative nervous system.These signals are transmitted to brain for appetite control.GPCRs also coordinate with other chemosensory signaling elements.The release of hormones can regulate energy and glucose homeostasis.The malfunction of GCPRs may be responsible for a variety of metabolic dysfunctions associated with overfeeding or obesity.In addition,another nutrient sensor system,mammalian target of rapamycin(mTOR) has been implicated as a sensor of nutrient sufficiency for dividing cells and is activated by essential amino acids,glucose and lipids.mTOR is also involved in the mechanisms for efficient transition between anabolic states and catabolic states.When nutrients are absorbed,the glucose will be transformed into liver glycogen or muscle glycogen for future utilization,and the lipids will be stored in adipose tissue.The glycogen will be used in pyrophosphorolysis and the lipids will be consumed by β-oxidation when energy is needed.When the nutrition storage exceeds some limits,mTOR will activate many processes that generate or use a large amount of energy and glycogen.It is increasingly apparent that mTORactivated metabolism impacts most major cellular functions,thus playing an oversized role in regulating basic cell behaviors such as growth and proliferation,and many disease including cancer,obesity,and type 2 diabetes.Furthermore,there is a ubiquitous natural phenomenon that the lifespan of an organism is closely related to its metabolic activity.The higher the metabolism speed,the shorter the lifespan,and vice versa.In recent years,multiple studies have shown that calorie restriction can prolong lifespan,so overnutrition may not only induce multiple diseases but also shorten lifespan.This review describes recent findings regarding overnutrition-related diseases.The main purpose is to attract extensive attention and broaden academic interest.
【Fund】: “十二五”国家科技支撑计划项目(2012BAD29B07);; 国家自然科学基金项目(30871951)
【CateGory Index】: R151.41
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 PANG Guang-chang,CHEN Qing-sen,HU Zhi-he,XIE Jun-bo(Tianjin Key Laboratory of Food Biotechnology,College of Biotechnology and Food Science, Tianjin University of Commerce,Tianjin 300134,China);Overview and Prospect of Food and Nutritional Epigenetics[J];Food Science;2011-17
2 PANG Guang-chang,CHEN Qing-sen,HU Zhi-he,XIE Jun-bo(Tianjin Key Laboratory of Food Biotechnology,College of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China);The “Five Flavor Conciliation ” and Nutrient Balance and Their Signal Transductions[J];Food Science;2012-13
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 GU Jin-Jin,ZHAO Tie-Yun,LI Xiu-Jun(Department of Endocrinology and Metabolism,West china Hospital of Sichuan University,Chengdu 610041,China);New Perspectives in the Treatment of Diabetes by Interfering With Glucagon Signaling Pathway[J];Progress in Physiological Sciences;2011-04
2 PANG Guang-chang,CHEN Qing-sen,HU Zhi-he,XIE Jun-bo(Tianjin Key Laboratory of Food Biotechnology,College of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China);The “Five Flavor Conciliation ” and Nutrient Balance and Their Signal Transductions[J];Food Science;2012-13
3 Zhi Yu, Youbing Xia, Chuanhui Ju, Qinghua Shao, Zhen Mao, Yun Gu, Bin XuKey Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of China, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China;Electroacupuncture regulates glucose-inhibited neurons in treatment of simple obesity[J];中国神经再生研究(英文版);2013-09
4 PANG Guang-chang,CHEN Qing-sen,HU Zhi-he,XIE Jun-bo(Tianjin Key Laboratory of Food Biotechnology,College of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China);Bioactive Peptides:Absorption,Utilization and Functionality[J];Food Science;2013-09
5 ZHANG Zhong-pina,SUN Chaob,MA Pei-yunb,ZHANG Zhaoa (a College of Veterinary Medicine,b College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi 712100,China);Effects of calcium signal on the transcription of GPR120 and adipogenesis in mouse adipose tissue[J];Journal of Northwest A & F University(Natural Science Edition);2010-09
6 Ze-Meng Feng,Li Wu,De-Zhi Fu,Dong Zhou,Zhi-Ru Tang,Yu-Long Yin,Hunan Engineering and Research Center of Animal and Poultry Science,Key Laboratory for Agro-ecological Processes in Subtropical Region,Institute of Subtropical Agriculture,Chinese Academy of Sciences,Changsha 410125,Hunan Province,China Ze-Meng Feng,Li Wu,De-Zhi Fu,Dong Zhou,Graduate School of the Chinese Academy of Sciences,Beijing 100039,China Zhen-Zhen Zhang,AsiaPac (Dongguan) Bio-technology Co.,Ltd.,Dongguan 523808,Guangdong Province,China;Progress in the understanding of GPCRs for free fatty acids[J];World Chinese Journal of Digestology;2011-08
7 WANG Jin-xia,REN Jian-gong,LI Yan-ni.(Department Two of Diabetes,the Second Hospital of Lanzhou University,Lanzhou 730030,China);Activity Regulation of AMP-activated Protein Kinase[J];Medical Recapitulate;2012-06
8 Hiroshi Taniguchi, Hajime Ariga, Jun Zheng, Kirk Ludwig, Toku Takahashi, Department of Surgery, Medical College of Wisconsin and Zablocki VA Medical Center, Milwaukee, Wisconsin, United States;Effects of ghrelin on interdigestive contractions of the rat gastrointestinal tract[J];世界胃肠病学杂志(英文版);2008-41
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 PANG Guang-chang,CHEN Qing-sen,HU Zhi-he (College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China);Tentative Review on Interactions of Food and Cytokine System as well as Food and Health(I)[J];Food Science;2006-05
2 PANG Guang-chang,CHEN Qing-sen,HU Zhi-he (College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China);Tentative Review on Interactions of Food and Cytokine System as well as Food and Health(II)[J];Food Science;2006-06
3 PANG Guang-chang(Tianjin Key Laboratory of Food Biotechnology,College of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China);Investigations for Origination and Development of Chinese Cooking Culture and Food Science[J];Food Science;2009-03
4 PANG Guang-chang,CHEN Qing-sen,HU Zhi-he,XIE Jun-bo (Tianjin Key Laboratory of Food Biotechnology,College of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China);Signaling Pathways of Dietary Phytochemicals for Health[J];Food Science;2010-19
5 PANG Guang-chang,CHEN Qing-sen,HU Zhi-he,XIE Jun-bo(Tianjin Key Laboratory of Food Biotechnology,College of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China);Wireless Communication Networks between Food and Human Body[J];Food Science;2010-21
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved