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Improvement of Pine Pollen on Learning and Memory Disorder of Mice Caused by Lead Poisoning

SHI Wei-lin;REN Zi-yan;CAO Cun-feng;WANG Fang;YANG Zhan-jun;School of Life Science,Huaiyin Normal University;  
Objective:To explore the improvement of pine pollen on learning and memory disorder caused by lead poisoning in mice.Methods:Mouse model of lead poisoning was established and the model mice were experimentally treated with pine pollen by gavage.After six weeks,the learning and memory ability were evaluated.Meanwhile,MDA content and monoamine oxidase(MAO),glutathione peroxidase(GSH-Px) and superoxide dismutase(SOD) activities in cerebral tissue were assayed.Results:Compared with the control group,the learning and memory ability of the mice from the model group were decreased(P 0.05 or P 0.01),and the activities of brain GSH-Px and SOD were significantly reduced(P 0.05),while MDA content and MAO activity exhibited a significant increase(P 0.05 or P 0.01).Compared with the model group,the learning and memory ability of the mice from the pine pollen group were improved(P 0.05) and the activities of GSH-Px and SOD were significantly enhanced(P 0.05),while MDA content and MAO activity were decreased(P 0.05).Conclusion:Lead poisoning can impair learning and memory ability of mice;however,pine pollen can rescue the impairment of learning and memory.
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