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《Chinese Journal of Chromatography》 1985-S1
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DETERMINATION OF FUROSEMIDE IN HUMAN PLASMA AND URINE BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

Yuan Yi-seng,Wu Chuang & Cai Ming-rui, General Hospital of Nanjing Command, PLA.  
A method for determination of furoscmide by reversed-phasc liquid chromatography was adopted with ODS column, methanol-phospliate buffer (32.5: 67.5, V/V), with pH 8.4 as mobile phase and a UV detector at 233nm . 0.5ml plasma or 1 ml urine with 0.75ml acetate buffer (pH4) added was shaken and th-organic layer was evaporated to dryness in air stream. The residue was redissolved with 0.5ml mobilee phase and 5μ1 was injected. This method was not interfered by other drugs. The average CV was ±3.3%with-in-day and ±8.6% day-to-day.The standard curve was linear (r= 0.9999) over a range of 0.4-20.0μg/m1, The average recovery was 93.8±2.0%.
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【References】
Chinese Journal Full-text Database 2 Hits
1 CHEN Gang;YUAN Yi-Sheng;ZHAO Yi;WU Chuang;CAI Ming-Rui General Hospital of Armed Forces of Nanjing, Nanjing First Teaching Hospital, Guangxi Medical College, Nanning First People's Hospital of Yunnan Province, Runming;A PHARMACOKINETIC AND PHARMACODYNAMIC STUDY ON FUROSEMIDE IN PATIENTS WITH CIRRHOSIS[J];The Chinese Journal of Clinical Pharmacology;1986-02
2 LIU Xiao-Quan, HUANG Sheng-Kai, LU Hong, YANG Jin-Yu Dept Pharmacology, China Pharmaceutical University, Nanjing 210009;Combined pharmacokinetic and pharmacodynamic model for furosemide in rabbits[J];Chinese Journal of Pharmacology and Toxicology;1991-02
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 ZHU Jia-Bi (Department of Pharmaceutics, Nanjing College of Pharmacy, Nanjing);STUDIES ON PHARMACOKINETICS AND PHARMACODYNAMICS OF FUROSEMIDE IN MAN[J];Acta Pharmaceutica Sinica;1986-05
2 Yang Jinyu, Liu Xiaoquan~1, Huang Shengkai~1 Analysis and Computer Center; ~1Department of Pharmacology;Computer Program for the Effect Parameters of Combined Pharmacokinetic and Pharmacodynamic Model[J];Journal of China Pharmaceutical University;1990-03
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