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《Chinese Journal of Chromatography》 1999-04
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Beaded Molecule Imprinted Polymer for Stereo Isomer Separation

Meng Zihui; Wang Jinfang; Zhou Liangmo; Wang Qinghai and Zhu Daoqian(Dalian Institute of Chemical Physics, the Chinese Academy of Sciences, Dalian, 116012) (Academy of Military Medicine Sciences, Beijing, 100850)  
Beaded molecule imprinted polymer (MIP) was made by suspension polymerization. Particles with the size of 50-70 μm in diameter were collected and evaluated in HPLC mode to separate stereo isomers.Stereo isomers cinchonine and cinchonidine were successfully discriminated with selectivity factor of 2.89 and resolution factor of 0.76. Stereo selectivity of the MIP was found to come from both the interaction between the analyte and carboxyl group on the MIP and the similarity between the stereo structure of imprinted molecule and the MIP. The thermal analysis results showed that the MIP had high thermal stability with initial thermal decomposition temperature of 320℃. The pore volume of the MIP was 0. 184 9 mL/g, the specific surface area was 126. 84 sqm/g and the average pore diameter was 5. 8 nanometer. Scanning electron microscopy showed that MIP had perfect spherical morphology.
【Fund】: 国家自然科学基金!No.29775025
【CateGory Index】: O658
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