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《Chinese Journal of Chromatography》 2003-03
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Separation and Determination of Fluoroquinolones with a Molecularly Imprinted Polymer

SUN Hui1, DONG Xiangchao1, L Xianyu2, WANG Haibo1, HAN Jianfang1 (1. Department of Chemistry, Nankai University, Tianjin 300071, China; 2. College of Life Science, Nankai University, Tianjin 300071, China)  
The molecularly imprinted polymer (MIP) was synthesized with ofloxacin as the template, methacrylic acid as the functional monomer, and pentaerythritol triacrylate as the crosslinker. Polymerization was initiated under 366 nm ultraviolet ray with 2,2'azobis (2methylpropionitrile) as the initiator. High performance liquid chromatography was employed to study the recognition property of the resulting MIP. The correlation of the selectivity of the imprinted polymer with mobile phase compositions was evaluated. It was shown that the ofloxacin imprinted polymer has specific selectivity and high affinity to the ofloxacin. The interactions between the MIP and target molecules were found to arise from the ionic and hydrogen bonding in the imprinted area and the hydrophobic interaction in the nonimprinted area. The retention of the fluoroquinolones decreased as the pH of the buffer (in the mobile phase) was decreased, and also decreased as the concentration of the aqueous buffer in the mobile phase was increased. Acetonitrile was a stronger solvent than methanol for eluting fluoroquinolones from the MIP column. Ofloxacin imprinted polymer could be used as the solidphase extraction and chromatographic separation medium for fluoroquinolones if column efficiency could be further improved. The possible causes for the low column efficiency of MIP were also discussed.
【Fund】: 天津市自然科学基金资助课题(项目编号:003602411).
【CateGory Index】: O658
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