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《Chinese Journal of Chromatography》 2004-04
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Enantiomeric Separation of Mandelic Acid and Its Analogues by High Performance Liquid Chromatography with 2,6-Di-O-Pentyl-β-Cyclodextrin Coated Symmetry C_8 Column

RUAN Yuanping~(1,2), ZHANG Xueman~(1,2), CHEN Anqi~1, QIU Haiyuan~1, HUANG Peiqiang~1(1. Department of Chemistry, Xiamen University, Xiamen 361005, China; 2. The Key Laboratory of AnalyticalSciences of Ministry of Education, Xiamen University, Xiamen 361005, China)  
Di-O-pentyl-β-cyclodextrin, synthesized from β-CD in dimethyl sulfoxide (DMSO), was dynamically coated on a Symmetry C_8 column through hydrophobic interaction. (Using) the coated column, the resolution of six racemic mixtures of mandelic acid and its (analogues) by reversed-phase high performance liquid chromatography was achieved: (±)-mandelic acid, (±)-mandelic acid methyl ester, (±)-mandelic acid ethyl ester, (±)-2-phenyl-glycine, (±)-phenylsuccinic acid and (±)-benzoin. The enantiomeric separation mechanism is discussed. The method can be applied conveniently to determine the enantiomeric excess of mandelic acid and its analogues.
【Fund】: 国家自然科学基金资助项目 (No .2 0 2 72 0 48 2 0 3 90 0 5 0 5 )
【CateGory Index】: O657.7
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