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《Food Science and Technology》 2004-10
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Antibiotic action mechanism and antibiotic efficacy of Nisin

LI Zeng-li(Dept of Biochemical Engineering,J iangs u Univers ity of S cience and Technology,Zhenjiang212004)  
Nis in belongs to the family of lantibi otics,a group of ribos omally s ynthes iz ed and pos t-trans lationlly modified peptide antibiotics which are characteriz ed by the occurrence of the uncommon a minoacids,s uch as lanthionine ands in leading to cell death propos e that the membrane of bacterial cell i s the primary target for nis in,nis in forms poration complexes in the membrane through a multis tep proces s of binding,ins ertion and pore formation,through t he pore a rapid efflux of ions and cytos olic s olutes takes place.The“barrel-s tave”model and the“wedge”model are the two common model for pore formation.N is in s hows antibacterial activity mainly agains t gram-pos itive bacteria.Anti biotic efficacy of nis in is dominated by the molecular s tructure and effected by the nature of target bacteria and the food s ys tem,s uch as nis in-res is ta nce,membrane dis rupting agents,s ublethal injury,temperature,pH,cation,proteoly tic enz ymes and other biopres ervatives.
【CateGory Index】: TS202.3
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