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《Asian Journal of Ecotoxicology》 2011-04
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Anti-apoptosis Effect of Natural Extracts on A549 Cell Apoptosis Induced by PM_(2.5)

Zu Guifang1, Jiang Wei2, Zhao Xiaohong1,*, Chang Di1, Shen Shen1 1. College of Arts and Sciences of Beijing Union University, Beijing 100191, China 2. Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China  
The mechanism of cell damage induced by fine particulate matter (PM2.5) and the anti-damage effect produced by natural extracts were studied by human lung carcinoma A549 cells as targets. MTT assay was used to measure the cytotoxicity, and apoptotic rate was detected by flow cytometry with Annexin V-FITC/PI double staining method. The results showed that PM2.5 stimulated the proliferation of A549 cells at lower concentration (150 mg·L-1), while PM2.5 inhibited the proliferation at higher concentration (≥150 mg·L-1). No significant cytotoxicity was observed in cells exposed to bamboo leaf extract and lingonberry extract but anti-cytotoxicity effects were shown at concentrations lower than 200 mg·L-1. Compared to the apoptotic rate induced by PM2.5, bamboo leaf extract could significantly decrease the apoptosis at 50 mg·L-1 and 100 mg·L-1 (p0.05). Lingonberry extract could reduce the apoptosis induced by PM2.5 with good dose-response relationship (r=-0.958, p0.05). The anti-apoptosis effect of bamboo leaf extract was higher than that of lingonberry extract at the same concentration (50 mg·L-1). The results suggested that the bamboo leaf extract and lingonberry extract would have no significant cytotoxicity but have antagonistic effect on PM2.5-induced apoptotic rate in certain concentration range.
【Fund】: 北京市自然科学基金(7092015)
【CateGory Index】: R285
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