Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Ecologica Sinica》 2006-05
Add to Favorite Get Latest Update

Review of factors affecting the taxoids content of Taxus spp.

WANG Chang-Wei 1,2, PENG Shao-Lin 1,*, LI Ming-Guang1, LI Wen-Jian2, LIN Fa-Liang2 (1. State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China;2.Fujian South Bio-tech. Co. Ltd., Mingxi County, Fujian 365200, China).  
The taxoids content of Taxus spp. is significantly affected by various factors and this review summarizes the main findings from many studies during the last 20 years. As many tries to industrialize its production can′t be realized due to high cost in the near future, cultivating Taxus spp. appears the most feasible and economical way to obtain these valuable compounds for use in medicine (chemotherapy) and basic research. The taxoids content of Taxus spp. responds to several factors including species, environment, season, age, sex, tissue, storage, hormones and side metabolic pathway inhibitors. Understanding the relative importance of these factors is critically important for increasing the content of taxoids in plant material, and hence the economic viability of this industry. There are large variations between species and cultivars, within and between Taxus spp. populations in taxoids content. A cultivar with comparatively high shoot taxol content, Taxus × media cv Hicksi, has been selected by the FDA as the best choice for cultivation whilst Taxus baccata L., supplies most of the world market with 10-deacetylbaccatin Ⅲ. In general, taxol accumulation is higher under shady and moist conditions whilst shoot growth (and hence taxol accumulation) is reduced in high light intensity and dry conditions. Total taxoids content usually peaks in winter while that of 10-deacetylbaccatin Ⅲ often peaks in fast-growing seasons. For mature trees, taxol content increases with the age of trees while no significant difference in taxol content was attributed to the sex of trees. 3-4 and 7-8 year-old seedlings often had lower taxol and 10-deacetylbaccatin Ⅲ contents than 1-year-old seedlings. Root and stem bark are richer in taxol than other tissues while small stems and needles often have higher 10-deacetylbaccatin Ⅲ or baccatin Ⅲ content. The decomposition rate of taxoids in dry plant material is reduced in shady conditions and at low temperature. Following collection, plant material should be processed quickly and carefully as studies show that heat, stacking and leaching by rain further reduce taxoids content. In addition, spraying the foliage with certain hormones and side metabolic pathway inhibitors could also increase the content of taxoids. This paper identifies several fields for further study: (1) to select and cultivate high-taxol strains, particularly of Taxus wallichiana var. mairei, the fastest growing and most widely distributed species in China; (2) to determine the mechanism responsible for the effect of soil components, particularly some rare earth elements on taxoids yield; (3) to establish how macro-ecological factors affect the production and accumulation of taxoids; (4) to identify the effects and mechanisms of hormones and side pathway inhibitors, and (5) to optimize the combination of those factors mentioned above to further improve taxoids content for application in production.
【Fund】: 广东省科技攻关资助项目(2004B20801002)~~
【CateGory Index】: S791.49;S567.19
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 WANG Chao et al(Department of Life Science,Yuanpei College,Shaoxing University,Shaoxing,Zhejiang 312000);Effect of Winter LED Supplementary Illumination on Growing Development of Taxus chinensis var.mairei Cheng et L.K[J];Journal of Anhui Agricultural Sciences;2012-12
2 Yang Fengjian,Pang Haihe,Zu Yuangang,Zhang Xueke(Key Laboratory of Forest Plant Ecology(Northeast Forestry University),Ministry of Education,Harbin 150040,P.R.China);Effect of Artificial Compound Community on Biomass and Taxol Content of Taxus chinensis var. mairei[J];Journal of Northeast Forestry University;2010-09
3 SONG Li-li et al(College of Ecological Technology and Engineering,Shanghai Institute of Technology,Shanghai 201418);Research Progress on Seedling Propagation Techniques and Growth Influencing Factors of Taxus chinensis[J];Horticulture & Seed;2011-05
4 LI Xin-Lei,LI Ji-Yuan,FAN Zheng-Qi,TIAN Min,ZHANG Xiao-Qing( The Research Institute of Subtropical Forestry,Chinese Academy of Forestry,Fuyang 311400,China );Growth characteristics of Taxus chinensis var. mairei under different cultivation conditions[J];Guihaia;2010-05
5 LI Feng-tao,RONG Jun-dong,CHEN Li-guang,GUO Xi-jun,ZHANG Ling-ling,ZHENG Yu-shan(Institute of Industrial Forest,Fujian Agriculture and Forestry University,Fuzhou,Fujian 350002,China);Advances in Taxus spp. based on GAP[J];Subtropical Agriculture Research;2008-02
6 PENG Liyuan,LI Yali,ZHAO Caiyun,WANG Chaoxia,WANG Chunying,WANG Chunxia(Key Laboratory of Eco-Textiles(Jiangnan University),Ministry of Education,Wuxi,Jiangsu 214122,China);Extraction of chlorophyll in Taxus chinensis and its sodium zinc chlorophyllin dyeing property to wool fabric[J];Journal of Textile Research;2013-05
7 YU Xianghua,SHAO Jinhua,YUAN Zhihui,ZHAO Changhui,DAI Yongqiang(Department of Life Science & Chemistry Engineering,Hunan Technology College,Yongzhou,Hunan 425100,China);Research Progress on Production of Taxol by Plant Cell Engineering[J];Acta Botanica Boreali-Occidentalia Sinica;2013-06
8 Su Jianrong Miao Yingchun Zhang Zhijun(Research Institute of Resource Insects,CAF Kunming 650224);RAPD Markers Related to Taxol Content of Taxus yunnanensis[J];Scientia Silvae Sinicae;2009-07
9 ZHOU Zhi-chun1,YU Neng-jian2(1.Research Institute of Subtropical Forestry,Chinese Academy of Forestry,Fuyang 311400,Zhejiang,China;2.Green Ecosystem Research Institute of Mingxi County,Fujian Province,Mingxi 365200,Fujian,China);Effect of Cultivation Measures on the Taxol Content of Taxus chinensis var. mairei[J];Forest Research;2010-01
10 LUO Fan,FEI Xue-qian,TANG Fu-bin,LI Xin-lei(Research Institute of Subtropical Forestry,Chinese Academy of Forestry,Fuyang 311400,Zhejiang,China);Simultaneous Determination of Paclitaxel in Hazelnut by HPLC-MS/MS[J];Forest Research;2011-06
【Citations】
Chinese Journal Full-text Database 6 Hits
1 Zhang Zongqin; Yang Jinxiang (Northwestern Institute of Botany, Yangling Shaanxi 712100);NATURAL RESOURCE OF TAXUS LINN AND ITS UTILIZATION IN QINBA MOUNTAINS[J];SHANXI FOREST SCIENCE AND TECHNOLOGY;1996-03
2 SUN Xiao yun ( Xi’an Sanjiang Bio EngineeringCo.,Ltd ,Xi’an 710201);STUDIES ON THE CHEMICAL CONSTITUENTS OF THE STEM OFACANTHOPANAX SETCHUENENSIS[J];Natural Product Research and Development;2001-02
3 LI Jing chuan 1, MA Zhong hai 1, YUAN Ying jin 1, SUN An ci 2, HU Chang xu 2 (1. Department of Biochemical Engineering, Tianjin University, Tianjin 300072, China; 2. Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China);Dynamic Effects of Cerium on Synthesis of Soluble Protein and Taxol in Suspension Culture of Taxus Chinensis Var. Maimei Cells[J];Journal of The Chinese Rare Earth Society;2001-02
4 Yuan Yingjin, Hu Guowu, Wang Chuangui, Jing Ying, Zhou Yongqia, Shen Panwen(Department of Chemistry and Engineering, Tianjin University, Tianjin 300072, China);Effect of Rare Earth Compounds on the Growths, Taxol Biosynthesis and Release of Taxus Cuspidata Cell Culture[J];JOURNAL OF THE CHINESE RARE EARTH SOCIETY;1998-01
5 Xiang Wei(Yunnan Academy of Forest Science Kunming 650204)Ruan Detrun Zhang Hongjie Mu Qing Sun Handong(Kunming lnstitute of Botany,Academy of Science of China,Kunming 650204);Taxol Content Analysis From Taxus vunnanensisin Different Places Of Yunnan Province[J];YUNNAN FORESTRY SCIENCE AND TECHNOLOGY;1996-02
6 \ Yang Lixin, Xu Jianchu (Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204), Li Lianfang (Yunnan Academy of Forestry Sciences, Kunming 650204),;The distribution and the present situation of utilization of Taxus L. resources in Yunnan Province and its protection and sustainable utilization[J];Journal of Plant Resources and Environment;1999-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Feng-wei et al(Department of Chemical and Biological Engineering,Yancheng Institute of Technology,Yancheng,Jiangsu 224051);Analysis on the Content of Taxol in Different Collection Season of Taxus cuspidata Branches and Leaves[J];Journal of Anhui Agricultural Sciences;2008-36
2 YANG Fei1,ZHANG Xiao-ping1,SUN Qi-wu2(1.College of Life Sciences,Anhui Normal University,Wuhu 241000,China;2.Research Institute of Forestry,Beijing 100091,China);In Vitro Embryo Culture of Taxus chinensis var. mairei[J];Journal of Anhui Normal University(Natural Science);2010-03
3 Li Yun; Liang Qingfeng; Cao Ziyi. School of Biological Sciences and Biotechnology, Beijing For. Univ., 100083, P.R.China.;Recent advances of studying on Taxus cell engineering.[J];Journal of Beijing Forestry University;2003-01
4 CHANG Zui1;ZHOU Zhi-qiang2;XIA Chun-mei3;LIU Tong3. 1 Key Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil Field of Ministry of Education,Alkali Soil Natural Environmental Science Center,Northeast Forestry University,Harbin,150040,P.R.China;2 Key Laboratory of Forest Plant Ecology of Ministry of Education,Northeast Forestry University,Harbin,150040,P.R.China;3 School of Forestry,Northeast Forestry University,Harbin,150040,P.R.China.;Characteristics of paclitaxel and cephalomannine content changing in the branches of natural Japanese yew.[J];Journal of Beijing Forestry University;2012-02
5 WU Yan\+1,LIU Qing\+1,HU Ke\+1,XU Wei hong\+2 (1.Chengdu Institute of Biology,The Chinese Academy of Sciences, Chengdu 610041, China;2 Sichuan Jiufeng Natural Medicine Co.,Ltd,Maoxian 623200, China);PRESENT STATUS OF TAXUS RESOURCES AND INDUSTRIAL DEVELEPMENTSTRATEGIES OF TAXOL IN CHINA[J];Resources and Environment in the Yangtze Basin;2002-06
6 Yang Fengjian,Pang Haihe,Zu Yuangang,Zhang Xueke(Key Laboratory of Forest Plant Ecology(Northeast Forestry University),Ministry of Education,Harbin 150040,P.R.China);Effect of Artificial Compound Community on Biomass and Taxol Content of Taxus chinensis var. mairei[J];Journal of Northeast Forestry University;2010-09
7 Zhao Zhilian1,Gu Peian1,Li Haifeng2 (1. Dali Agriculture School,Dali ,Yunnan 671003,China;2. College of Pharmacology,Dali University,Dali,Yunnan 671000,China);The Effect of Rare Earth Chemical Elicitor on the Cell Growth and the Synthesis of 10-Deacetyl Baccatin Ⅲ of Taxus yunnanensis Cell Culture[J];Journal of Dali University;2009-12
8 Zhang Xinyie (Hubei Academy of Forestry Wuhan 430079);Protection and Sustainable Utilization of Taxus Resources in Our Country[J];Hubei Forestry Science and Technology;2002-02
9 ZHENG Deyong(College School of Material Engineering,Fujian Agriculture and Forestry University,Nanping 353001,China);Study on the Taxol Content in Different Parts of Taxus Growing in China[J];Journal of Fujian College of Forestry;2003-02
10 CHEN Ying,XIE Yinfeng,CAO Fuliang(College of Forest Resource and Environment Nanjing Forest University, Nanjing 210037,China);Application and Research Progress of Rare Earths in Field of Plant Tissue and Cell Culture[J];Journal of Fujian College of Forestry;2003-04
China Proceedings of conference Full-text Database 1 Hits
1 KE Chun-ting TONG Chuan WANG Yu-zhen (Fujian South Bio-tech.Co.Ltd.,Sanming 365200,China;Provincial Key Laboratory of Subtropical Resources and Environment,School of Geography,Fujian Normal University,Fuzhou 350007,China);Taxol and 10-DAB contents in Taxus Chinensis of different provenance and its affecting factors[A];[C];2008
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 CHANG Ming-jin et al(Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agriculture Science,Haikou,Hainan 571101);Research and Development of Natural Medicine Taxol[J];Journal of Anhui Agricultural Sciences;2006-02
2 ZHOU Wen-jie et al(Department of Life Science,Hengshui University,Hengshui,Hebei 053000);Research on Biological Characteristics of Taxus media[J];Journal of Anhui Agricultural Sciences;2007-08
3 WU Xiao-ming et al (Jingdezhen Institute of Forestry Science,Jingdezhen,Jiangxi 333000);Effects of Cutting with Different Matrixes on the Survival Rate of Taxus chinensis[J];Journal of Anhui Agricultural Sciences;2009-29
4 ZHANG Yan-jie et al(College of Life Science,Jiangxi Normal University,Nanchang,Jiangxi 330022);Study on the Biological Characteristics of Taxus chinensis var.mairei Seeds[J];Journal of Anhui Agricultural Sciences;2010-01
5 XU Yu-mei et al (Yunnan Academy of Forestry,Kunming,Yunnan 650204);Effect of Different Treatments of Fertilizers on the Growth Increments of Taxus yunnanensis Seedlings[J];Journal of Anhui Agricultural Sciences;2011-05
6 Wang Jiyong; Wang Wenquan;Liu Yong. School of Resources and Environment,Beijing For.Univ.,100083,P.R.China.;Effects of tree and medicinal plant intercropping system on medicinal plants' yield.[J];Journal of Beijing Forestry University;2003-06
7 CHENG Guang_you1; GAO Feng2; GE Chun_hua2; TANG Xiao_jie1. 1 Forestry College, Beihua University, Jilin, 132013, P.R.China;2 Forestry Bureau of Yongji County of Jilin Province, 132200, P.R.China.;Variation regularity of taxol content in natural populations of Taxus cuspidata Sieb. et Zucc. in China.[J];Journal of Beijing Forestry University;2005-04
8 YANG Shui-ping1;YANG Xian1,2;ZHANG Xue3;HUANG Jian-guo1;WANG Bo-chu2;ZHU Liancai2. 1 Key Laboratory of Eco-environments in Three Gorges Reservoir Region of Ministry of Education,College of Resource and Environment,Southwest University,Chongqing,400716,P.R.China;2 Bioengineering College,Chongqing University,400044,P.R.China;3 Chongqing Academy of Chinese Materia Medica,400065,P.R.China.;Chromatographic fingerprint identification of active components in cultivated Taxus chinensis var. mairei[J];Journal of Beijing Forestry University;2010-04
9 Zhang Yueling1) Li Junquan2) Xiao Zun'an1)(1)College of Life Sciences,Beijing Normal University,100875,Beijing,China;2)Campus Maintenance and Administration Office,Beijing Normal University,100875,Beijing,China);REGULATION OF TAXOL CONTENT IN CELLS IN VITRO OF TAXUS BREVIFOLIA AND T.GLOBOSA[J];Journal of Beijing Normal University(Natural Science);2007-04
10 WU Yan\+1,LIU Qing\+1,HU Ke\+1,XU Wei hong\+2 (1.Chengdu Institute of Biology,The Chinese Academy of Sciences, Chengdu 610041, China;2 Sichuan Jiufeng Natural Medicine Co.,Ltd,Maoxian 623200, China);PRESENT STATUS OF TAXUS RESOURCES AND INDUSTRIAL DEVELEPMENTSTRATEGIES OF TAXOL IN CHINA[J];Resources and Environment in the Yangtze Basin;2002-06
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Wen Xuejun(Bureau of Forestry of Mingxi County,Mingxi 365200,China);Research on the Affect Conditions of Taxus chinensis Var.mairei Growth Characteristics[J];Anhui Agricultural Science Bulletin;2012-07
2 LI Jiao-hua1,ZHANG Xiao-ping1,SUN Qi-wu2,LU Zhao-yang3,CHEN Yi-kun1(1.Key Laboratory for the Conservation and Utilization of Important Biological Resources,Anhui Province,College of Life Sciences,Anhui Normal Uiniversity,Wuhu 241000,China;2.Forestry Research Institute of Chinese Academy,Beijing 100091, China;3.College of Society,Anhui Normal University,Wuhu 241000,China);Advances on Research of Apomictic Technology About Taxus chinensis Var. Mairei[J];Journal of Anhui Normal University(Natural Science);2011-01
3 CHANG Zui1;ZHOU Zhi-qiang2;XIA Chun-mei3;LIU Tong3. 1 Key Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil Field of Ministry of Education,Alkali Soil Natural Environmental Science Center,Northeast Forestry University,Harbin,150040,P.R.China;2 Key Laboratory of Forest Plant Ecology of Ministry of Education,Northeast Forestry University,Harbin,150040,P.R.China;3 School of Forestry,Northeast Forestry University,Harbin,150040,P.R.China.;Characteristics of paclitaxel and cephalomannine content changing in the branches of natural Japanese yew.[J];Journal of Beijing Forestry University;2012-02
4 Yang Fengjian,Pang Haihe,Zu Yuangang,Zhang Xueke(Key Laboratory of Forest Plant Ecology(Northeast Forestry University),Ministry of Education,Harbin 150040,P.R.China);Effect of Artificial Compound Community on Biomass and Taxol Content of Taxus chinensis var. mairei[J];Journal of Northeast Forestry University;2010-09
5 Liu Tong(School of Forestry,Northeast Forestry University,Harbin 150040,P.R.China);Chang Zui,Wang Yang(Key Laboratory of Saline-Alkali Vegetation Ecology Restoration in Oil Field(Northeast Forestry University),Ministry of Education/Alkali Soil Natural Environmental Science Center);Zhou Zhiqiang(Key Laboratory of Forest Plant Ecology(Northeast Forestry University),Ministry of Education);Differences in Contents of Paclitaxel and Cephalomannine in Taxus cuspidate of Different Ages and Sexes[J];Journal of Northeast Forestry University;2011-12
6 LIAO Guo-hua(Extension Center for Forestry Scientific and Technology of Sanming City,Sanming,Fujian 365000,China);Cultivation of high-yield,short rotation,medicinal plantation of Taxus wallichiana var. mairei[J];Fujian Journal of Agricultural Sciences;2009-01
7 WEI Mei-yu,LIU Li-ping,CHEN Shi-jun(Department of Life Science,Qiannan Normal University for Nationalities,Duyun,Guizhou 580000,China);Physiological Indexes Related to Senescence of Wild Taxus chinensis in Swampy Environment of Doupeng Mountain in Guizhou[J];Guizhou Agricultural Sciences;2010-12
8 SONG Li-li et al(College of Ecological Technology and Engineering,Shanghai Institute of Technology,Shanghai 201418);Research Progress on Seedling Propagation Techniques and Growth Influencing Factors of Taxus chinensis[J];Horticulture & Seed;2011-05
9 LI Xin-Lei,LI Ji-Yuan,FAN Zheng-Qi,TIAN Min,ZHANG Xiao-Qing( The Research Institute of Subtropical Forestry,Chinese Academy of Forestry,Fuyang 311400,China );Growth characteristics of Taxus chinensis var. mairei under different cultivation conditions[J];Guihaia;2010-05
10 JIN Ming-zhong et al.(Jingning Forestry Resultant Field in Zhejiang Province,Jingning,Zhejiang 323500);Study on Raising Seedlings by Sowing of Abies firma S.et.Z[J];Horticulture & Seed;2012-11
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Bai Weilan (College of Landscape Architecture, Beijing For.Univ.,100083, P.R.China)\= Ren Jianwu\= (College of Plant Sciences,Beijing For.Univ.,100083,P.R.China) \= Su Xuehen\= (College of Landscape Architecture,Beijing For.Univ.,100083,P.R.China);Comparative Study on Shade\|Tolerance of Eight Garden Plants[J];JOURNAL OF BEIJING FORESTRY UNIVERSITY;1999-03
2 Xu Shoumin Shi Lianxuan Hu Bo Zhu Changfu Deng Conghui Gao Liqin (School of Life Sciences, Northeast Normal University,Changchun,130024);Changes in Photosynthetic Capacity and Related Enzyme Activities during Soybean(Glycine max) Leaf Senescence[J];JOURNAL OF NORTHEAST NORMAL UNIVERSITY (NATURAL SCIENCE EDITION);1997-04
3 Zhao Jian,Zhu Weihua and Wu Yunqi ( Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College ,Beijing 100050);KINETIC STUDY ON ISOENZYMES AND ACTIVITIES OF SEVERAL ENZYMES IN SINENXANS HIGH YIELD CELL LINE Ts19 IN TISSUE CULTURES OF TAXUS CHINENSIS[J];ACTA BOTANICA BOREALI-OCCIDENTALIA SINICA;1998-03
4 Zhang, Ya-Fei Niu, Chun-Ji~* Ni, Jia-Zuan(Changchum, Institute of Applied Chemistry, Academia Sinica, Changchum, 130022);Study on Complexes of Rare Earth with L-Phenylalanine by Potentiometry and Calorimetry[J];Acta Chimica Sinica;1992-02
5 Liu Pei, Jiao Yubihg, Lui Chuanyu,Xu Junmei,Suen Chao, and Kang Jianhua(Institute of Petrochemistry,Heilongjiang Academy of Sciences, Harbin 150050);Development of Taxol—the New antitumer Agent[J];CHEMISTRY AND ADHESION;1998-03
6 Zhu Genhai, Liu Zuqi and Zhu Peiren(Section of Plant Physiology, Nanjing Agricultural University);A STUDY ON DETERMINATION OF LETHAL TEMPERATURE WITH LOGISTIC FUNCTION[J];Journal of Nanjing Agricultural University;1986-03
7 Lin Dingbo; Liu Zuqi (Dept of Hortic, Zhejiang Agric Univ, HangZhou 310029;Dept of Agronomy, Nanjing Agric Univ, Nanjing 210014);EFFECT OF COLD ACCLIMATION AND ABA ON MEMBRANE STABILITY AND SYNTHESIS OF MEMBRANE PROTEIN IN CITRUS[J];JOURNAL OF NANJING AGRICULTURAL UNIVERSITY;1994-01
8 LU Chang\|mei,WU Guo\|rong,ZHOU Chang\|fang,GU Gong\|ping (The Life Science College, Nanjing Normal University,Nanjing,210097,PRC);The Effects of Illumination on Plant SOD Activity[J];JOURNAL OF NANJING NORMAL UNIVERSITY(NATURAL SCIENCE EDITION);2000-03
9 Cai Shiying Zhou Qianping Pan Qiuhong (Tropical Crops Department,SCCTC);EFFECTS OF ABA ON REGULATION OF RESISTANCE OF COFFEE SEEDLINGS TO CHILLING INJURY[J];Chinese Journal of Tropical Crops;1990-02
10 Wang Shaohui (Dept. of Horticulture Shandong Agri.Univ.Taian,China,271018) Hao Cuiling (Dept. of Biology.Jingouzhai Middle School,Yantai,China,264001) Zhang Zhenxian (Dept. of Horticulture Shandong Agri.Univ.,Taian,China,271018);THE STUDY AND ADVANCE IN THE SHADE EFFECT OF PLANT[J];Journal of Shandong Agricultural University;1998-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved