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《Progress in Modern Biomedicine》 2009-11
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Effects of Modified Apple Polysaccharides on the Apoptosis of Human Colon Cancer HT29 cells

WU Huan-jie1,GAN Hong-quan1,LI Yu-hua1,NIU Ying-bo2,SUN Yang1,LIU Li1,MEI Qi-bing1 (1 Department of Pharmacology,School of Pharmacy,Fourth Military Medical University,710032,Xi'an,China; 2 Faculty of Life Sciences,Northwestern Polytechnical University,710072,Xi'an,China)  
Objective:To investigate the effects of modified apple polysaccharides(MAP)on the apoptosis of human colon cancer HT29 cells and the mechanisms.Methods:The effects of different doses of MAP on proliferation of HT29 cells were observed by MTT assay,and the effects of MAP on the apoptosis of HT29 cells were investigated by TUNEL assay and flow cytometric analysis.And Western Blot was employed to determine the expressions of caspase 3,8,9,Bax and Bcl-2 of HT29 cells after given MAP.Results:MAP can inhibit proliferation of HT29 cells significantly in a dose-dependent manner in contract to control.And MAP can also induce the apoptosis of HT29 cells,increase the expression of caspase 3,8,9 and Bax and decrease the expression of Bcl-2 in HT29 cells dose-dependently.Conclusions:MAP could induce apoptosis of HT29 cells.And it seems that MAP exerts this function through both the intrinsic and extrinsic ways of apoptosis.
【CateGory Index】: R735.35
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Chinese Journal Full-text Database 4 Hits
1 HUANG Zhi-liang, LIU Hai-ying Department of Abdominal Surgery, Affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou 510095, China;Expression of galectin-3 in liver metastasis of colon cancer and the inhibitory effect of modified citrus pectin[J];Journal of Southern Medical University;2008-08
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