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《Progress in Modern Biomedicine》 2009-12
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Progress of High Methylation On Cerical Cancer Related Gene Promoter

LIU Xiao-wan1, MA Yi-nu'er·niyazi2△ (1 Shihezi University School of Medicine, 832000, Shihezi, China; 2 People's Hospital OF XinJiang Uygur Autonomous Region, 830001, Urumqi, China)  
This paper introduces the molecular level in cervical cancer occurrence and development process of tumor suppressor genes methylation. It is said that HPV infection risk of cerical cancer is the main factor to occur. With the development of science and technology, cervical tissue tumor suppressor genes and the methylation get more and more attention. Always think gene mutations and lack substance in chromosome inactivation of tumor suppressor genes are the main reasons. However, the CPG promoter methylation cause abnormal island of gene inactivation in cancer development plays a very important role had proved conclusively, DNA methylation is the third for tumor suppressor genes deactivation mechanism, and in some cases are the only mechanism. The organization for cerical cancer to relevant tumor-suppressor gene screening of methylation and application in cancer detection as mark, which occurred in preventing cervical cancer, also can play an important role for cerical cancer to test a curative effect.
【Fund】: 国家自然科学基金项目(30760279)
【CateGory Index】: R737.33
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