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《Progress in Modern Biomedicine》 2009-15
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Cyclooxygenase -2 and Lung injury

GAO Wei1,2,ZHANG Dong2,LIU Jiang-wei2(1 Medical College of Shihezi University,Shihezi,Xinjiang 832000 China;2 Department of hepatobiliary Surgery,Urumuqi General Hospital of Lanzhou Military region Urumuqi 830000,China)  
Lung injury refers to the cell degeneration or necrosis of lung and the changes of pulmonary function caused by various pathogenic factors including physical,chemical and biological factors.Many inflammatory mediators and cytokines involved in the process of lung injury.As an inducible enzyme,Cyclooxygenase -2(COX-2) could be high expression when cells were stimulated by inflammation,which was an important determinant of inflammation-mediated cytotoxicity.The high expression of COX-2 in lung injury caused by various reasons reveals that COX-2 may play an important role in the genesis and development of lung injury.It would be a highlight in the study of therapy of lung injury in targeting on COX-2 in the future.
【Fund】: 兰州军区医药卫生科研基金资助项目(LXH-2005019)
【CateGory Index】: R563
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