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《Progress in Modern Biomedicine》 2009-16
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Expression and significance of EGFR and EGFRvⅢ in gastric carcinoma

FAN Ping1,ZOU Sai-ying2,ZHAO Hai-hua2 (1 Medical collage of Shihezi University,Shihezi,832002,China; 2 Department of Pathology,Urumqi General Hospital Lanzhou Command,PLA,Urumqi 830000,China)  
Objective:To detect expression of epidermal growth factor receptor (EGFR)and epidermal growth factor receptor variantⅢ (EGFRvⅢ) in gastric carcinoma to explore its relation with the genesis and development of gastric carcinoma and its relation-ship with clinicopathological parameters. Methods:Immunohistochemistry (S-P) was used to detect the expression of EGFR and EGFRv Ⅲ protein in one hundred and five gastric carcinoma tissues and their adjacent normal gastric tissues. Results:Positive expression rate of EGFR and EGFRvⅢ in gastric carcinoma tissues were higher than normal gastric tissues (P0.01),their positive expression rate were 46.67%,35.24% and 7.62%,3.81%. Their expression were unrelated with gender and age of gastric carcinoma(P0.05),but were close-ly related with the degree of differentiation,depth of invasion,lymph node metastasis and clinical stages (P0.05). Conclusion:Many gastric carcinoma tissues have overexpression of EGFR and EGFRvⅢ,which may play certain role in the genesis and development of gastric carcinoma and closely related the degree of differentiation,depth of invasion,lymph node metastasis and clinical stages.
【CateGory Index】: R735.2
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 OU Chao1, WU Fei-xiang2, LUO Yuan3, CAO Ji1, ZHAO Yin-Nong2,YUAN Wei-Ping2, LI Yuan1, SU Jian-Jia11. Department of ExperimentPathology, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China2. Department of Hepatobiliary & Breast, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China3. Department of Clinical Pathology, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China;Expression and Significance of Epidermal Growth Factor Receptor Variant Type Ⅲ in Hepatocellular Carcinoma[J];Chinese Journal of Cancer;2005-02
2 Duan Xiaoyi1,Wang Jiansheng2,Zhang Mingxin2,Xia Peng2(1.Department of Nuclear Medicine;2.Department of Oncosurgery,the First Affiliated Hospital,Medical School of Xi'an Jiaotong University,Xi'an 710061,China);Expression and significance of epidermal growth factor receptor variant Ⅲ in human suprarenal epithelioma[J];Journal of Xi'an Jiaotong University(Medical Sciences);2008-04
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 HE Jian-Bin1, YI Gao-Zhong1, YANG Kai1, XIANG Zhi1, XIE Mao-Feng1, ZHANG Ping21. Department of Respiratory Diseases, The First People’s Hospital of Huaihua City, Huaihua, Hunan, 418000, P. R. China 2. Department of Respiratory Diseases, The First Affliliated Hospital, Nanhua University, Hengyang, Hunan, 421001, P. R. China;Inhibitory Effects of Suramin on Growth of Transplanted Lung Adencarcinoma in Mice and Its Mechanisms[J];Chinese Journal of Cancer;2008-04
2 Zhao Yinnong,He Ni,Ou Chao,et al.(Department of Hepatobiliary and Breast, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021 China);EXPRESSION AND SIGNIFICANCE OF EGFR AND EGFRvⅢ IN HUMAN BENIGN MAMMARY HYPERPLASIA AND BREAST CANCER[J];Journal of Guangxi Medical University;2008-01
3 ZHAO Yin-nong1,HE Ni2,OU Chao1,CAO Ji1,CHEN Jun1,LIU Jian-Yong1,YUAN Wei-Ping1 1.Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,P.R.China 2.Department of Surgery,Guangxi Minzu Hospital,Nanning 530001,P.R.China;Expressions and clinical significance of EGFR and EGFRv Ⅲ in mammary tumor[J];Chinese Journal of Cancer Prevention and Treatment;2007-03
4 Duan Xiaoyi1,Wang Jiansheng2,Zhang Mingxin2,Xia Peng2(1.Department of Nuclear Medicine;2.Department of Oncosurgery,the First Affiliated Hospital,Medical School of Xi'an Jiaotong University,Xi'an 710061,China);Expression and significance of epidermal growth factor receptor variant Ⅲ in human suprarenal epithelioma[J];Journal of Xi'an Jiaotong University(Medical Sciences);2008-04
5 BO Ai-hua~1,CHENG Lin~2,LI Hai-feng~1,et al.(1.Central laboratory of Hebei North University,Zhangjiakou 075000,China;2.The Department of Sugery,the Third Hospital of North College in Herbei,Zhangjiakou 075000);Dependability of Epidermal Growth Factor Receptor and Tumor in Genesis and Treatment[J];Medical Recapitulate;2006-20
6 Bo Aihua Lu Guangping Yan Aichun et al Department of Electron Microscopy, Hebei North University Zhangjiakou;Expression of EGFR and VEGF and Its Significance in Breast Cancer[J];Chinese Journal of Clinical Oncology;2007-23
7 XU Li1, ZHANG Chang-qing2, FENG Kai-tao2, LI Jin-qing1 ( 1. Department of Hepatobiliary Oncology, 2. Central Laboratory, State Key Laboratory of Oncology of Southern China // Cancer Center, SUN Yat-sen University, Guangzhou 510060, China);Clinical Significance of EGFR and EGFRvⅢ Expression in Tumor and Liver Tissue of HCC[J];Journal of Sun Yat-Sen University(Medical Sciences);2006-04
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 OU Chao1, WU Fei-xiang2, LUO Yuan3, CAO Ji1, ZHAO Yin-Nong2,YUAN Wei-Ping2, LI Yuan1, SU Jian-Jia11. Department of ExperimentPathology, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China2. Department of Hepatobiliary & Breast, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China3. Department of Clinical Pathology, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China;Expression and Significance of Epidermal Growth Factor Receptor Variant Type Ⅲ in Hepatocellular Carcinoma[J];Chinese Journal of Cancer;2005-02
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