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《Progress in Modern Biomedicine》 2009-20
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Stress hormones and hemodynamic change during and after Carbon dioxide pneumoperitoneum under general anesthesia and general-epidural combined anesthesia

ZHANG Jiu-xiang,DAI Zhi-gang,GAO Yuan-li,GUO Su-xiang(Department of Anesthesiology,First Affiliated Hospital,Shihezi University,School of Medicine Shihezi,832000,Shihezi xinjiang,China)  
Objective:To observe stress hormones and hemodynamic change during and after Carbon dioxide pneumoperitoneum in laparoscopic cholecystectomy(LC) under general anesthesia and general-epidural combined anesthesia.Methods:40 patients of LC were divided into general anesthesia group(A group n=20) and general-epidural anesthesia group(B group n=20) randomly.All patients'SBP,DBP,MAP,HR,ECG,SpO2,PETCO2 are monitored continuously.Record SBP,DBP,MAP,HR before anesthesia,after tracheal intubation,at 10min 20min after pneumoperitoneum and at 10min after the removal of pneumoperitoneum,meanwhile,plasma concentration of blood glucose(Glu),cortiso(lCor),adrenocorticotropin(ACTH)and angiotensinⅡ(AT-Ⅱ)were measured.Results:Before anesthesia,all measured value did not differ much between group A and group B(P0.05);after tracheal intubation,at 10min 20min after pneumoperitoneum and at 10min after the removal of pneumoperitoneum,SBP,DBP,MAP in group A increased significantly than those in group B(P0.05);HR and the concentrations of Glu,Cor,ACTH,AT-Ⅱ were increased significantly after peritoneal insufflation of CO2 in group A(P0.05),while there were no changes in group B(P0.05).There was difference between two groups(except for ACTH)(P0.05).Conclusion:There was a relative advantage in reducing the stress hormones caused by Carbon dioxide pneumoperitoneum and stabilizing the hemodynamic in LC under general-epidural anesthesia.
【CateGory Index】: R614
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