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《Progress in Modern Biomedicine》 2013-27
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The Effects of Huperzine A on Memory and ARC of ECT Rats

CHENG Jing;LI Cheng-yan;WANG Gao-hua;CHEN Zheng-hua;XIAO Ling;Department of Psychiatry, Renmin Hospital of Wuhan University;Department of Neurology, Renmin Hospital of Wuhan University;  
Objective: To investigate effects of Huperzine A on memory induced by Electroshock therapy(ECT) and the expression of Activity-regulated cytoskeletal-associated gene(ARC).Methods: Adult male Wistar rats were randomly divided into receive Huperzine A or normal saline(control).These treatments were administered during experiment day 1-17.During experiment day 8-17,true or sham ECT was administered.At the experiment day 18 the rats were trained and tested in Morris water maze.Then the rats were randomized to receive 90 sec probe tests 48 hr after training to measure retention or decapitated quickly to take the hippocampus for detecting ARC expression 1 hour after training.Results: ECT resulted in significant amnesia in rats.The level of ARC mRNA and protein in ECT group was significant lower than those in sham ECT group.However,the memory of ECT rats treated with Huperzine A maintained better and the level of ARC mRNA and protein were significantly higher than those of ECT rats treated with saline.There was no significant difference between ECT rats treated with Huperzine A and sham ECT rats.Conclusions: Huperzine A administered before the ECT may attenuate ECT-induced amnesia.Huperzine A can reduce the effect of ECT on the expression of ARC.ARC may play a role in the development of spatial memory impairment caused by ECT.
【Fund】: 国家自然科学基金项目(81201058)
【CateGory Index】: R285.5
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