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《Progress in Modern Biomedicine》 2015-17
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Expression and Clinical Significance of FSTL1 in Peripheral Blood and Intestinal Tissues of Ulcerative Colitis

YI Rui;WANG Juan;CHANG Juan;HAO Nan;General Hospital of Beijing Military Command;Medical School of PLA;66011 Troops;  
Objective: To study the expression and significance of follistatin-like protein 1(FSTL1) in peripheral blood and intestinal tissues of patients with ulcerative colitis(UC). Methods: Patients with ulcerative colitis in our hospital from March 2013 to March 2014 were selected as the study group(n=60), and subjects with normal pathology and colonoscopy were chosen as the control group(n=60). FSTL1 levels in the peripheral blood of the two groups were detected by ELISA, and the FSTL1 level in the intestinal tissues of the two groups were detected by the immunohistochemical staining. Then the correlation between the ulcerative colitis activity index(DAI) and FSTI1 were analyzed by Pearson correlation analysis. Results: The plasma FSTL1 level of the study group was significantly higher than that of the control group with statistically significant difference(t=11.063, P=0.025). The positive rate of FSTL1 in the intestinal tissues of the study group was significantly higher than that of the control group with statistically significant difference(x2=12.987, P=0.019); DAI and FSTI1 of the study group was positively correlated(r=0.719, P=0.023). Conclusion: The FSTL1 expression level was elevated in patients with ulcerative colitis, and was positively correlated with disease activity.
【Fund】: 国家自然科学基金青年科学基金项目(81301239)
【CateGory Index】: R574.62
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