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《Journal of Biomedical Engineering》 2005-05
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Experimental Study of the Lethal Effects of Steep Pulsed Electric Field on Cancer Cells in BALB/c Mice

Yao Chenguo 1 Sun Caixin 1 Mi Yan 1 Xiong Lan 1 Hu Ya 2 Hu Lina 2 1(Key Lab of High Voltage Engineering and Electrical New Technology, Ministry of Education, Chongqing University, Chongqing 400044, China) 2(Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400010, China)  
This study was conducted to observe the lethal effects of steep pulsed electric field(SPEF) on the cancerous squamous cells in BALB/c mice.Female mice were inoculated with the solution of cervical cancer cells line.The tumor-bearing mice of the experiment group were exposed to SPEF. Then, the histomorphological changes were examined and compared between experiment group and control group. The histological and antitumor assay showed that SPEF could selectively injure tumor cells and inhibit cell proliferation. After treatment, pyknosis, karyoclasis and karyolysis of cancer cells were observed under light and electron mircroscope. More serious changes appeared some days later. These results indicate that SPEF have lethal effects on cervical cancer. It may prolong the survival period of tumor-bearing mice.
【Fund】: 国家自然科学基金资助项目(50077027)
【CateGory Index】: R73-3
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【References】
Chinese Journal Full-text Database 1 Hits
1 LI Chengxiang1,YAO Chenguo1,MI Yan1,SUN Caixin1,XIONG Zheng'ai2,LING Xiaojuan2,GU Huayan2(1.Key Laboratory of High Voltage and Electrical New Technology of Ministry of Education,Chongqing University,Chongqing 400044,China;2.Second Affiliated Hospital,Chongqing Medical Science University,Chongqing 400061,China);Dosimetry Study on Irreversible Electrical Breakdown of Rabbit Liver Tissue Under Steep Pulsed Electric Field[J];High Voltage Engineering;2007-02
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Yao Chenguo 1 Sun Caixin 1 Mi Yan 1 Xiong Lan 1 Hu Lina 2 1(Key Lab of High Voltage Engineering and Electrical New Technology, Chongqing University, Chongqing 400044, China) 2(Second Affiliated Hospital,Chongqing University of Medical Science, Chongqing 400010, China);Development of Energy-controllable Steep Pulse Apparatus for Tumor Treatment[J];Chinese Journal of Scientific Instrument;2003-06
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 Mi Yan Sun Caixin Yao Chenguo Li Chengxiang Mo Dengbin (Chongqing University Chongqing 400030 China);Frequency Response of Transmenbrane Potential on Cell Inner and Outer Membrane Based on Equivalent Circuit Model[J];Transactions of China Electrotechnical Society;2007-06
2 MI Yan1,SUN Caixin1,YAO Chenguo1,LI Chengxiang1,MO Dengbin1,TANG Liling1,2,LIU Huan2(1.Key Laboratory of High Voltage Engineering and New Technology of Ministry of Education,College of Electrical Engineering,Chongqing University,Chongqing 400044,China;2.Bioengineering College of Chongqing University,Chongqing 400030,China);Effect of Steep Pulsed Electric Field(SPEF) on Mitochondrial Transmembrane Potential(MTP) of Liver Cancer Cell[J];High Voltage Engineering;2007-02
3 Mi Yan Sun Caixin Yao Chenguo Xiong Lan Wang Shibin Luo Xiaodong Hu Lina (The Key Laboratory of High Voltage Engineering and Electrical New Technology, Ministry of Education, Chongqing University, Chongqing 400044. China) (The Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China);Effect of Steep Pulsed Electric Fields on the Immune Response of Tumor-bearing Wistar Mice[J];Journal of Biomedical Engineering;2007-02
4 YAO Chen-guo 1, SUN Cai-xin 1, MI Yan 1, XIONG Lan 1, HU Ya 2, HU Li-na 2 (1.Key Lab of Ministry of Education for High Voltage Engineering and Electrical New Technology, Chongqing Universify,Chongqing 400044; 2.Second Affiliated Hospital, Chongqing Medical Science University, Chongqing 400010);EXPERIMENTAL STUDY OF LETHAL AND INHIBITORY EFFECTS ON TUMOR-BEARING MICE UNDER STEEP PULSED ELECTRIC FIELD[J];Chinese Journal of Biomedical Engineering;2004-06
5 MI Yan 1 SUN Cai-Xin1 YAO Chen-Guo1 LI Cheng-Xiang1 MO Deng-Bin1 TANG Li-Ling 1,2 LIU Huan2 1(State Key Laboratory of Power Transmission Equipment & System Security and New Technology,Chongqing University,Chongqing 400044) 2(Bioengineering College of Chongqing University,Chongqing 400044);Effect of Steep Pulsed Electric Field (SPEF) on Intracellular Free Calcium Concentration of Liver Cancer Cells in vitro[J];Chinese Journal of Biomedical Engineering;2008-04
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 YAO Chen-guo, SUN Cai-xin, XIONG Lan, MI Yan, WANG Shi-bin Under the State Ministry of Education, Chongqing University, Chongqing 400030, China);Irreversible Electrical Breakdown of Malignant Tumor Cell Under Steep Pulsed Electric Fields[J];Journal of Chongqing University(Natural Science Edition);2004-06
2 ;Experimental Study on Irreversible Electrical Breakdown of Malignant Tumor Cell under Steep Pulse[J];High Voltage Engineering;2003-01
3 SUN Cai-xin 1 , YAO Chen-guo 1 , XIONG Lan 1 , MI Yan 1 , LIAO Rui-jin 1 , HU Li-na 2 , HU Ya 2 (1.Key Laboratory of High Voltage Engineering and Electrical New Technology,Ministry of Education,Chongqing 400044,China;2.Second Affiliated Hospital,Chongqing University of Medical Science,Chongqing 400010,China);KILLING EFFECTS OF PULSED ELECTRIC FIELDS ON MALIGNANT TUMOR CELL[J];Acta Biophysica Sinica;2002-04
4 YAO Chen-guo1, SUN Cai-xin1, MI Yan1, XIONG Lan1, LIAO Rui-jin1, HU Li-na2, HU Ya2 (1. Key Lab of High Voltage Engineering and Electrical New Technology, Ministry of Education, Chongqing 400044; 2. Second Affiliated Hospital, Chongqing Medical Science University, Chongqing 400061);EXPERIMENTAL STUDY ON IRREVERSIBLE ELECTRICAL BREAKDOWN OF MALIGNANT TUMOR CELL UNDER STEEP PULSE[J];Chinese Journal of Biomedical Engineering;2004-01
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 XIANG Peng1,3,LI Cheng-Xiang1,LIAO Rui-Jin1,YAO Chen-Guo1,MI Yan1,XIONG Zheng-Ai2,GU Hua-Yan2(1.The State Key Laboratory of Power Transmission Equipment & System Security and New Technology,Chongqing University,Chongqing 400044,China;2.Second Affiliated Hospital Chongqing Medical Science University,Chongqing 400061,China;3.No.77118 Hospital of PLA,Chengdu 618408,China);Electric Intensity Threshold of Irreversible Electric Breakdown of Rabbit Liver VX_2 Tumor Under Steep Pulse Electric Field[J];High Voltage Engineering;2008-10
2 WUJing1,XIONG Zheng-ai1,LI Cheng-xiang2,YAO Cheng-guo2,SUN Cai-xin2,YANG Xiao-yan1,ZHAO Dong-yang21. Department of Obstetrics and Gynecology,The Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010,China;2. Key Lab of High Voltage Engineering and Electrical New Technology of Ministry of Education,Chongqing University,Chongqing 400044,China;An Experimental Study of the Effects of Steep Pulse Treatment on Liver Cancer of Rabbit Monitored by Ultrasound[J];Journal of Southwest University(Natural Science Edition);2009-01
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