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《China Biotechnology》 2009-10
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Progress in Ginsenosides Biosynthesis and Prospect of the Secondary Metabolic Engineering for the Production of Ginsenosides

WU Qiong ZHOU Ying-qun,SUN Chao CHEN Shi-lin(Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100193,China)  
Ginsenosides,which belongs to triterpenoid saponins of plant terpenoids,are the main active components of the valuable medicinal herbs ginseng and American ginseng.Recent studies show that ginsenosides have a variety of beneficial effects,including anti-inflamatory,antioxidant,and anticancer effects.Ginsenosides are synthesized by complicated modification of triterpenoid skeleton after cyclization of 2,3-oxidosqualene through triterpene saponin synthesis pathway in which they share common early steps with phytosterols synthesis.It outlines recent advances for the biosynthesis of ginsenosides,the cloning and characterization of genes encoding key enzymes in the pathway and the basal framework of ginsenosides biosynthesis pathway.The prospects of secondary metabolism engineering in the biosynthesis of plant natural products and its application in ginsenosides biosynthesis are also discussed.
【Fund】: 国家自然科学基金(30873459)资助项目
【CateGory Index】: Q943
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