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《China Biotechnology》 2010-03
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Advances on Cyanobacteria Genetic Engineering Applications

XI Chao1 WANG Chun-mei1 SHI Ding-ji2,3 (1 Department of Biopharmaceuticals,School of Materia Medica,Beijing University of Chinese Medicine,Beijing 100102,China) (2 School of Marine Science and Engineering,Tianjin University of Science and Technology,Tianjin 300450,China) (3 Institute of Botany,Chinese Academy of Sciences,Beijing 100093,China)  
Cyanobacteria are used as a host of gene engineering to express foreign gene,their unique properties gradually attracting scientists' attention.The stable cyanobacteria transformation system has been constructed since 1990.In the past 20 years,more than 30 foreign genes have been successfully expressed in cyanobacteria.With the further investigation,cyanobacteria transgenic expression system has the potential to be extensively used for production of recombinant drugs,clean energy resources,farm chemical and for preventing the environment pollution et al.This review summed up the development of cyanobacteria genetic engineering and their uses in medicine,environment,agriculture and biosensor.Then,this review analyzed the development bottlenecks of the cyanobacteria transgenic engineering,the low expression rate of the foreign gene in cyanobacteria.Finally,it summarized the efforts that many scientists have made to improve the low expression rate,including:choosing high efficient gene and oral preparation,optimize transcription and translation component,adjust the host cell`s physiological state,et al.
【Fund】: 国家“973”计划(2007CB512605);; 教育部留学回国人员科研启动基金资助项目
【CateGory Index】: Q78
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