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《CHINESE JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY》 2000-02
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Advances in DNA Chip Technology

LI Ling,MA Wen li (Institute of Molecular Biology,The First Military Medical University,Guangzhou 510515,China)  
In DNA chip technology,light directed in situ oligonucleotide synthesis or microarray printing technique has been adopted, to generate arrays of large amounts of probes in the surface of small substrates such as silicon chips,which hybridize to the amplified and labeled samples.After scanning and analysing,the signals can provide information on the identity of samples.By this novel method,not only DNA sequencing and gene expression monitoring but also genome research and gene diagnoses can be performed.Though faced with some difficulties in the hardware and software at present,bright future has been envisioned.
【Fund】: 国家自然科学基金!资助项目 ( 3 9880 0 3 2 )
【CateGory Index】: Q789
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