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《Chinese Journal of Biochemistry and Molecular Biology》 2001-04
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The Effects Cholecystokinin Octapeptide on CaM and PKC Activities in Rat Cerebral Cortex Neurocytes

XIANG Peng,CHEN Man ling,WU Zhao feng (Laboratory of Hormone receptor,Department of Biochemistry,West China University of Medical Sciences,Chengdu 610041,China)  
To investigate the effects of cholecystokinin octapeptide(CCK 8)on camodulin(CaM),protein kinase C(PKC)and 3′,5′ cyclic AMP,the rat cerebral cortex neurocytes were used as model.No cAMP accmulations could be observed,except for a high concentration(10 -5 mol/L).On the other hand,evidence of CCK 8 induced CaM and PKC activiation was found in a dose dependent manner.The CCK B selective antagonist L 365,260 and the CCK A selective receptor antagonist L 364,718 were able to block a maximal effect of CCK 8 induced CaM and PKC activation.But the IC 50 were different.The effect of L 364,718 was evidently weaker than that of L 365,260.All these results suggest that CCK 8 may regulate signal transduction in rat cerebral cortex through CCK B receptor.
【CateGory Index】: Q57
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