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《Chinese Journal of Biochemistry and Molecular Biology》 2003-04
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ATP-Dependent Physical Remodeling of Chromatin

YI Xia, SHANG Yong\|feng * (Department of Biochemistry and Molecular Biology, Oncology Center, Peking University Health Science Center, Beijing 100083, China)  
Chromatin remodeling is an integral part of the process involved in gene transcriptional regulation. Chromatin remodeling is achieved through ATP dependent physical modifications and covalent chemical reactions. ATP dependent chromatin remodeling factors use the energy of ATP hydrolysis to introduce superhelical torsion into DNA and to alter the rotational phasing of the DNA on the surface of the histone octamer, thus to increase the accessibility of the nucleosomal DNA to transcription factors and restriction enzymes.
【Fund】: 国家高科技研究发展计划资助项目 (863计划 ) (No .2002BA711A0 1 0 5 );; 国家杰出青年科学基金资助项目(No .3 0 2 2 5 0 43 )~~
【CateGory Index】: Q754
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【References】
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【Co-references】
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1 Lu Dezhao1,Wo Xingde2 1.College of Life Science,Zhejiang Chinese Medical University,Hangzhou(310053); 2.College of Preclinical Medicine,Beijing University of Chinese Medicine;The Status and Considerations of Study on Kidney-Yang Deficiency[J];Journal of Zhejiang University of Traditional Chinese Medicine;2007-03
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