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《Chinese Journal of Bioprocess Engineering》 2007-04
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The therapeutic effects of Cordyceps polysaccharide on occluding renal artery-induced acute kidney injury in dog

YIN Hong-ping1,LV Xiao-bo2,CHEN Xi2(1.School of Life Science and Technology,China Pharmaceutical University,Nanjing 210009,China;2.School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210046,China)  
The therapeutic effects of Cordyceps polysaccharide(CP) on occluding renal artery-induced acute kidney injury in dog were studied,36 adult dogs were randomly divided into six groups,sham operation group,model group,Cordyceps polysaccharide group CP 160 mg/kg,CP 80 mg/kg and CP 40 mg/kg,and Dexamethasone group.The models of acute renal failure were established by occluding renal artery.After management,renal function,biochemical indicator,urine routine and renal pathologic changes were observed.Compared with the model group,the degree of injury of renal function in Cordyceps polysaccharide group dogs were palliated significantly(P0.01),renal pathologic changes were palliated significantly.Cordyceps polysaccharide has a remarkable effect on renal ischemia-induced acute kidney injury.The mechanisms could be relevant to improving renal function,increasing renal blood flow,correcting metabolic disorder,and promoting regeneration of renal tubule.
【Fund】: 国家自然科学基金资助项目(30500458)
【CateGory Index】: S858.292
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