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《Letters in Biotechnology》 2001-02
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Angiostatin and endostatin as suppressors on tumor growth

SUN Ning Xia, ZHANG Ping Wu (The Second Military Medical Universiey, Shanghai 200433, P.R.China)  
Angiogenesis is a key limiting step in tumor growth and metastasis. The control of angiogenesis has emerged as an important mechanism of suppressing tumor growth. Recent discoveries of endogenous negative of regulators of angiogenesis--angiostatin and endostain suggest a new paradigm of tumorigenesis. This review is concerned about their identification?molecular biology?bioactivity, especially their antitumor effects. Although there remains some problems about their treatment for cancer, the studies of angiostain and endostain is likely to create a new therapeutic options.
【CateGory Index】: R730.2
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1 YU Lei (School of Food and Pharmaceutical,Harbin University of Commerce,Harbin 150076,China);Effection of traditional Chinese medicine on tumor angiogenesis[J];Journal of Heilongjiang Commercial College (Natural Sciences Edition);2002-04
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