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《Acta Biophysica Sinica》 2002-04
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SUN Cai-xin 1 , YAO Chen-guo 1 , XIONG Lan 1 , MI Yan 1 , LIAO Rui-jin 1 , HU Li-na 2 , HU Ya 2 (1.Key Laboratory of High Voltage Engineering and Electrical New Technology,Ministry of Education,Chongqing 400044,China;2.Second Affiliated Hospital,Chongqing University of Medical Science,Chongqing 400010,China)  
In order to observe the lethal effects of pulsed electric fields (PEFs) of different parame-ter combinations (frequency, peak value of voltage, width of pulse) on malignant tumor cell, every PEF was applied to malignant tumor cell suspension (3 ml) in the test bottle for 20 min. The MTT method was used to test the mortality ratio of tumor cell and growth curve was plotted. The ultrastructural varia-tions of treated cells were inspected and compared with the untreated cells. The results showed that PEFs of different combinations had great influence on tumor cell. With the increasing of parameter value, the mortality ratio of tumor cell was rising and cell proliferation was inhibited. The treated cell was swollen and the membrane was destroyed. The mitochondria was also cavitated and swollen.
【Fund】: 国家自然科学基金项目(50077027)
【CateGory Index】: R73-36
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