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《Acta Biophysica Sinica》 2004-03
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STUDY ON MOLECULAR MECHANISM OF ECHINACOSIDE FOR AGAINST AGING

MUTELIEFU Gulinuer1,LEI Li2,TU Peng-fei2,GUO De-an1,LU Jing-fen1(1.The State Key Laboratory of Natural and Biomimetic drugs,Peking University,Beijing 100083,China;2.School of Pharmaceutical Science,Peking University,Beijing 100083,China)  
It was investigated that the scavenging abilities of Echinacoside (ECH) to reactive oxygen species (ROS) in vitro and in vivo,as well as the molecular mechanism for anti-aging by ECH. The inhibitory effect of ECH on ·OH?O2· and L· free radicals in vitro was evaluated with spin trapping EPR method. Cryogenic EPR technique was used to detect the generation of reactive oxygen species (ROS) in heart, liver, kidney and brain of an aged mice induced by D-galactose (D-gal). The content of MDA in liver homogenate, the activities of MAO in brain homogenate, and whole blood GSH-Px were determined by biochemistry method; The activity of SOD in serum was calculated from spin trapping EPR spectra. The memory potency of mouse was checked using step down test. The results showed that ECH possessed a good scavenging potency on ·OH?O2· and L· free radicals in vitro, they could repair the damages induced by aging, as well as enhance the activities of GSH-PX and SOD, reduce the content of MDA. ECH could improve the memory ability from decreasing the activity of MAO. It was concluded that ECH might delay aging process and inhibit the lipid peroxidation, which related to their antioxidative function.
【Fund】: 联合利华合作基金项目
【CateGory Index】: Q946
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