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《生物医学与环境科学(英文版)》 2002-03
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Abnormal Reactions of Free Radicals and Oxidative Damages in the Bodies of Patients With Chronic Glomerulonephritis

ZHOU JUN-FU1, CHEN JIA-XI, SHEN HAN-CHAO, AND CAI DONG The Second Affiliated Hospital, Medical College of Zhejiang University, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China  
Objective To study the abnormal reactions of a series of free radicals and the oxidative damages induced by free radical abnormal reactions in the bodies of patients with chronic glomerulonephritis. Methods Eighty chronic glomerulonephritis patients (CGNP) and eighty healthy adult volunteers (HAV) were enrolled in a random control study, in which concentrations of nitric oxide (NO) in plasma, lipoperoxides (LPO) in plasma and in erythrocytes, and vitamin C (VC), vitamin E (VE) and beta-carotene (?CAR) in plasma as well as activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in erythrocytes were determined with spectrophotometric assays. Results Compared with the average values of the above biochemical parameters in the HAV group, the average values of NO in plasma, and LPO in plasma and erythrocytes in the CGNP group were significantly increased (P = 0.0001), while those of VC, VE and -CAR in plasma as well as those of SOD, CAT and GPX in erythrocytes in the CGNP group were significantly decreased (P = 0.0001). Pearson product-moment correlation analysis showed that with increase of the concentration of blood creatinine as well as prolongation of the course of disease in the CGNP, the concentrations of NO in plasma, and LPO in plasma and erythrocytes in the CGNP increased gradually, while the concentrations of VC, VE and ?CAR in plasma as well as the activities of SOD, CAT and GPX in erythrocytes in the CGNP decreased gradually (P = 0.002454 0.000001). The relative risk ratio (RR) of the above biochemical parameters reflecting oxidative damages in the bodies of CGNP ranged from 6.061 to 72.429. The reliability coefficient (alpha) that the above biochemical parameters were used to reflect the oxidative damages of the CGNP was 0.8137, standardized item alpha = 0.9728, Hotelling抯 T-Squared = 1135680.191, F = 53274.6478, P = 0.000001. Conclusions The findings in this study show that in the bodies of CGNP a series of free radical chain reactions result in severe pathological aggravation and induce oxidative damages in their bodies. Therefore, suitable dose of antioxidants should be supplemented to them so as to alleviate oxidative damages in their bodies.
【CateGory Index】: R692.3
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1 WANG Han-Min 1,2, WU Xiong-Fei1, TAN Hua2, CHEN Guang-Lei2, LI Feng3 1Department of Nephrology, Xi'nan Hospital, Third Military Medical University, Chongqing 400038, China, 2Department of Nephrology, 3Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Effects of ligustrazine on cell apoptosis and expressions of Bcl-2 and Bax in rat kidneys with ischemia-reperfusion injury[J];Journal of the Fourth Military Medical University;2006-20
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6 ZHOU JUN FU, YAN XIAO FENG, GUO FANG ZHEN, SUN NING YA, QIAN ZHI JUN, AND DING DE YUN The 2nd Affiliated Hospital of the Zhejiang University, 68 Jiefang Road, Hangzhou, 310009, Zhejiang Province, China;Effects of Cigarette Smoking and Smoking Cessation on Plasma Constituents and Enzyme Activities Related to Oxidative Stress[J];生物医学与环境科学(英文版);2000-01
7 XIE BO*,1, ZHOU JUN-FU#, LU QUN#, LI CHONG-JIAN#, AND CHEN PENG#*Huzhou Municipal Central Hospital, 106 Hongqi Road, Huzhou, 313000, Zhejiang,China; # The Second Affiliated Hospital, Medical College of Zhejiang University,88 Jiefang Road, Hangzhou 310009,;Oxidative Stress in Patients With Acute Coxsackie Virus Myocarditis[J];生物医学与环境科学(英文版);2002-01
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1 QIU Qing-Yan,QIN Jian,ZHENG Wei-Ping,GAO Dian-Sa,ZHAO Qian Department of Cardiology,First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China;Effects of PI3K/Akt signaling pathway on vascular endothelial function and interventional effects of erythropoietin[J];Journal of the Fourth Military Medical University;2009-22
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