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《生物医学与环境科学(英文版)》 2007-05
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Inhibitory Effect of Progesterone on Inflammatory Factors After Experimental Traumatic Brain Injury

DE-SHENG PAN*, WEI-GUO LIU#, XIAO-FENG YANG*,1, AND FEI CAO* *Department of Neurosurgery, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310003, Zhejiang, China; #Department of Neurosurgery, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, Zhejiang, China  
Objective Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality in young people. Inflammatory cytokines play an important part in the pathophysiology of TBI. Recent studies demonstrate that progesterone significantly reduces cerebral edema and enhances functional recovery from TBI and stroke in several animal models. This study was designed to investigate the inhibitory effect of progesterone on inflammatory response after traumatic brain injury. Methods Progesterone was injected intraperitoneally using rats as a model of traumatic brain injury, and Western blot technique was applied to detect the expression of three inflammation-related factors: nuclear factor kappa B p65 (NFκB p65), glial fibrillary acidic protein (GFAP), and tumor necrosis factor-α (TNF-α). The water content of injured brain was also examined. A neurological severity score was recorded to evaluate the effect of progesterone on neurodeficit recovery. Results NFκB p65, GFAP, and TNF-α were increased in all injured animals. In rats treated with progesterone, the expression level of NFκB p65 and TNF-α were reduced significantly in comparison with vehicle-treated rats. However, progesterone did not alter the expression of GFAP in the injured rats. Progesterone also reduced the water content of injured brain and the lesion volume. In addition, progesterone-treated injured rats showed significant improvements in the Neurological Severity Score test, compared with vehicle-treated ones. Conclusions Progesterone inhibits the inflammatory response after experimental traumatic brain injury and mitigates the severity of brain damage.
【CateGory Index】: R651.15
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Chinese Journal Full-text Database 7 Hits
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5 LEI Peng ZHANG Xing-chao PENG Long-feng Department of Neurosurgery,General Hospital of Lanzhou Military Command,Lanzhou 730050, China;Effect of erythropoietineffects on protein expressions of IL-1βand S100βin rats with severe brain injury and hemorrhagic shock[J];Chinese Journal of Trauma;2007-09
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7 YIN Yuan1,XU Shao-lin1,GU Guo-zhen2.(1.Department of Ophthalmology,The Second Hospital of Jilin University,Changchun 130041,China;2.Institute of Frontier Medical Sciences,Changchun 130021,China);Neuroprotection of PROG in rat acute ocular hypertention model[J];Chinese Journal of Laboratory Diagnosis;2008-08
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