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《生物医学与环境科学(英文版)》 2007-05
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Inhibitory Effect of Progesterone on Inflammatory Factors After Experimental Traumatic Brain Injury

DE-SHENG PAN*, WEI-GUO LIU#, XIAO-FENG YANG*,1, AND FEI CAO* *Department of Neurosurgery, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310003, Zhejiang, China; #Department of Neurosurgery, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, Zhejiang, China  
Objective Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality in young people. Inflammatory cytokines play an important part in the pathophysiology of TBI. Recent studies demonstrate that progesterone significantly reduces cerebral edema and enhances functional recovery from TBI and stroke in several animal models. This study was designed to investigate the inhibitory effect of progesterone on inflammatory response after traumatic brain injury. Methods Progesterone was injected intraperitoneally using rats as a model of traumatic brain injury, and Western blot technique was applied to detect the expression of three inflammation-related factors: nuclear factor kappa B p65 (NFκB p65), glial fibrillary acidic protein (GFAP), and tumor necrosis factor-α (TNF-α). The water content of injured brain was also examined. A neurological severity score was recorded to evaluate the effect of progesterone on neurodeficit recovery. Results NFκB p65, GFAP, and TNF-α were increased in all injured animals. In rats treated with progesterone, the expression level of NFκB p65 and TNF-α were reduced significantly in comparison with vehicle-treated rats. However, progesterone did not alter the expression of GFAP in the injured rats. Progesterone also reduced the water content of injured brain and the lesion volume. In addition, progesterone-treated injured rats showed significant improvements in the Neurological Severity Score test, compared with vehicle-treated ones. Conclusions Progesterone inhibits the inflammatory response after experimental traumatic brain injury and mitigates the severity of brain damage.
【CateGory Index】: R651.15
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【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 XU Shao-lin1,YIN yuan1,GU Guo-zhen2,GAO Zhi-zhuo1(1.Department of Ophthalmology,Second Hospital,Jinlin University,Changchun 130041,China;2.Department of Bioengineering,Institute of Frontier Medical Sciences,Jinlin University,Changchun 130021,China);Neuroprotection of progesterone on retinal ganglion cells in chronic ocular hypertension model rats[J];Journal of Jilin University(Medicine Edition);2008-02
2 QU Qiang,SHI Zhong△ (Department of Emergency,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Changes of TNF-α,IL-1β and cortisol in serum and hepatic GR following severe traumatic brain injury[J];Chongqing Medicine;2007-18
3 He Lu, ZHAI Li-dong, LI Yun-sheng, LI Xue-mei, YANG Hui. Department of Anatomy, Tianjin Medical University, Tianjin 300070 China;The anti-oxidant effect of progesterone on the learning and memory capability in ovariectomized mice[J];Anatomy Research;2009-01
4 HE Jia-yi*, WEI Jing-wang, ZHANG Jian-sheng. *Department of Neurosurgery, The Second Affiliated Hospital, Lanzhou University, Lanzhou Gansu 730030, China;Effect of Glucocorticosteroid on Plasma Levels of TNF-α and IL-1 β in Patients with Severe Traumstic Brain Injury[J];Chinese Journal of Clinical Neurosurgery;2007-01
5 LEI Peng ZHANG Xing-chao PENG Long-feng Department of Neurosurgery,General Hospital of Lanzhou Military Command,Lanzhou 730050, China;Effect of erythropoietineffects on protein expressions of IL-1βand S100βin rats with severe brain injury and hemorrhagic shock[J];Chinese Journal of Trauma;2007-09
6 LU Chuan, SUN Jun, CHEN Xiandong, et al. Wenzhou Second People's Hospital, Wenzhou 325000, China;Changes in levels of cerebrospinal fluid TNF- α、IL- 6 in patients with acute brain trauma[J];Zhejiang Journal of Traumatic Surgery;2008-03
7 YIN Yuan1,XU Shao-lin1,GU Guo-zhen2.(1.Department of Ophthalmology,The Second Hospital of Jilin University,Changchun 130041,China;2.Institute of Frontier Medical Sciences,Changchun 130021,China);Neuroprotection of PROG in rat acute ocular hypertention model[J];Chinese Journal of Laboratory Diagnosis;2008-08
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