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《Proceeding of Clinical Medicine》 2013-07
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Effect of Ginkgolide C in cardiac function of rats in the body

ZHAO Ting,SU Zhong-ping,ZHU Li-li,Xu MAO-chun,ZHOU Dian,DONG Wei,HAO Yan-ling(Xuzhou Medical College,Xuzhou 221004,China)  
ObjectiveTo study the effect of Ginkgolide C(GC) in cardiac function of rats in the body.Methods : Normal rats after anesthetized,inserted the intubate which connecting the pressure transducer into left ventricular from the right common carotid artery,then detected the cardiac function by the PowerLab biological signal acquisition system.Gave each of saline,1‰dimethyl sulfoxide(DMSO),100 μ mol / L GC,1 000 μ mol / L GC 1ml from the jugular vein,detected the cardiac function before and after administration by continuous recording the left ventricular systolic pressure(LVSP),left ventricular end diastolic pressure(LVEDP),the maximal rate of pressure increase in systole phase(+dp / dtmax),maximal rate of pressure decrease in diastole phase(-dp / dtmax) and heart rate(HR).Results : Compared with normal conditions,when given 100 μ mol / L GC,there are no significant effect on cardiac function;when given 1 000 μ mol / L GC,it showed inotropic activity by increasing △LVP,+dp / dtmax,-dp / dtmax significantly,but had no significant effect on HR.Conclution : Ginkgolide C can increase△LVP significantly,enhances the myocardial systolic and diastolic function of rats,but has no significant effect on HR while it shows inotropic activity.
【Fund】: 江苏省大学生实践创新训练计划省级项目(项目编号:2012JSSPITP1857)
【CateGory Index】: R285.5
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